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About This Item
Linear Formula:
ClC6H3(F)NH2
CAS Number:
Molecular Weight:
145.56
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
Assay
97%
refractive index
n20/D 1.564 (lit.)
bp
214 °C (lit.)
density
1.324 g/mL at 25 °C (lit.)
functional group
chloro
fluoro
SMILES string
Nc1cccc(Cl)c1F
InChI
1S/C6H5ClFN/c7-4-2-1-3-5(9)6(4)8/h1-3H,9H2
InChI key
XWBTZHDDWRNOQH-UHFFFAOYSA-N
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General description
3-Chloro-2-fluoroaniline is a dihalo-substituted aniline. Its enthalpy of vaporization at boiling point (487.15K) is 42.561kjoule/mol.
Application
3-Chloro-2-fluoroaniline may be used in the preparation of 2-chloro-3-fluorobromobenzene and 4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
230.0 °F - closed cup
Flash Point(C)
110 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Synthesis of 2-Chloro-3-fluorobromobenzene [J].
Zhao HY and Pan YQ
Chemical World, 11, 010-010 (2011)
Yaws CL.
Thermophysical Properties of Chemicals and Hydrocarbons, 522-522 (2014)
Min Wang et al.
Bioorganic & medicinal chemistry letters, 24(18), 4455-4459 (2014-08-26)
The reference standard AZD8931{2-(4-((4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)-N-methylacetamide} (11a) was synthesized from methyl 4,5-dimethoxy-2-nitrobenzoate or ethyl 4,5-dimethoxy-2-nitrobenzoate and 2-chloro-N-methylacetamide in 11 steps with 2-5% overall chemical yield. The precursor N-desmethyl-AZD8931{2-(4-((4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)acetamide} (11b) was synthesized from methyl 4,5-dimethoxy-2-nitrobenzoate or ethyl 4,5-dimethoxy-2-nitrobenzoate and 2-bromoacetamide in 11 steps
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