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1301007

USP

Guaifenesin

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Guaiacol glyceryl ether, 3-(o-Methoxyphenoxy)-1,2-propanediol, Glycerol guaiacolate, Guaifenesin

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About This Item

Empirical Formula (Hill Notation):
C10H14O4
CAS Number:
93-14-1
Molecular Weight:
198.22
MDL number:
MFCD00016873
UNSPSC Code:
41116107
PubChem Substance ID:
329749971
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

guaifenesin

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

COc1ccccc1OCC(O)CO

InChI

1S/C10H14O4/c1-13-9-4-2-3-5-10(9)14-7-8(12)6-11/h2-5,8,11-12H,6-7H2,1H3

InChI key

HSRJKNPTNIJEKV-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Guaifenesin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Acetaminophen and Diphenhydramine Citrate Tablets
  • Dyphylline and Guaifenesin Oral Solution
  • Dyphylline and Guaifenesin Tablets
  • Guaifenesin
  • Guaifenesin and Codeine Phosphate Oral Solution
  • Guaifenesin Capsules
  • Guaifenesin Compounded Injection, Veterinary

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Robert R Fayzullin et al.
Journal of pharmaceutical sciences, 103(10), 3176-3182 (2014-08-06)
The solubility of 3-(2-methoxyphenoxy)-propane-1,2-diol, the well-known chiral drug guaifenesin 1, in water has been investigated by means of polythermal and isothermal approaches. It was found that the solubilities of racemic and enantiomeric diols rac- and (R)-1 depend strongly on temperature.
Clinical inquiries. Is guaifenesin safe during pregnancy?
Roberto Silva et al.
The Journal of family practice, 56(8), 669-670 (2007-08-03)
Stephen Bennett et al.
Journal of alternative and complementary medicine (New York, N.Y.), 10(6), 967-969 (2005-01-28)
Ephedrine and guaifenesin are herbal supplements that have experienced increased use over the past decade. Ephedrine has been used as a stimulant and weight-loss product, guaifenesin as an expectorant and cough suppressant; both are found in combination in many antitussives
Manujendra Ray et al.
Hospital practice (1995), 37(1), 60-63 (2010-09-30)
Adverse drug reactions lead to a significant number of hospital admissions each year and thus contribute to the overall financial burden of health care. Some of these drug reactions are allergic responses. As the overall predictability of allergic responses to
William Storms et al.
Current allergy and asthma reports, 9(2), 101-106 (2009-02-13)
Mucus in the airways is a complex mixture of water, lipids, glycoproteins, sugars, and electrolytes that serves as a lubricant for the epithelium. The efficient flow of respiratory mucus is a first level of immune defense that requires an appropriate
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