SML2277

A192621

≥98 (HPLC)

• Synonym(s): (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-[(2,6-diethylphenyl)amino]-2-oxoethyl]-2-(4-propoxyphenyl)-3-pyrrolidinecarboxylic acid, A-192621
• Empirical Formula (Hill Notation): C₃₃H₃₈N₂O₆
• CAS Number: 195529-54-5
• Molecular Weight: 558.66
• UNSPSC Code: 12352200
• MDL number: MFCD05662209
• NACRES: NA.21
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: O=C(NC1=C(CC)C=CC=C1CC)CN(C[C@H](C2=CC3=C(OCO3)C=C2)[C@H]4C(O)=O)[C@H]4C5=CC=C(OCCC)C=C5
• InChI: 1S/C33H38N2O6/c1-4-16-39-25-13-10-23(11-14-25)32-30(33(37)38)26(24-12-15-27-28(17-24)41-20-40-27)18-35(32)19-29(36)34-31-21(5-2)8-7-9-22(31)6-3/h7-15,17,26,30,32H,4-6,16,18-20H2,1-3H3,(H,34,36)(H,37,38)/t26-,30-,32+/m1/s1
• InChI key: LQEHCKYYIXQEBM-FUKIBTTHSA-N

Description

Biochem/physiol Actions

A192621 is a selective; orally available ETB endothelin receptor antagonist. A192621 has been shown to cause an increase in arterial blood pressure and to promote apoptosis in human pulmonary arterial smooth muscle cells.

Selective; orally available ETB endothelin receptor antagonist

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable