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Key Documents

SAB4500422

Sigma-Aldrich

Anti-ADORA2A antibody produced in rabbit

affinity isolated antibody

Synonym(s):

ADORA2, ADORA2A, Adenosine receptor A2a

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 44 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100

NCBI accession no.

P29274

UniProt accession no.

P29274

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ADORA2A(135)

General description

Anti-ADORA2A Antibody detects endogenous levels of total ADORA2A protein.
Adenosinergic A2A receptor (ADORA2A) is a G-protein-coupled receptor and is expressed in the brain. It is located on human chromosome 22q11.23.

Immunogen

The antiserum was produced against synthesized peptide derived from human ADORA2A.

Immunogen Range: 120-169

Biochem/physiol Actions

Activation of the adenosine A2a receptor (ADORA2A) prevents T-cell proliferation and production of pro-inflammatory cytokines. Mutations in adenosinergic A2A receptor (ADORA2A) controls the psychomotor vigilance and the effects of caffeine in NREM (non-rapid-eye movement) sleep.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Polymorphisms of ADORA2A modulate psychomotor vigilance and the effects of caffeine on neurobehavioural performance and sleep EEG after sleep deprivation
Bodenmann S, et al.
British Journal of Pharmacology, 165(6), 1904-1913 (2012)
Adenosine A(2A) receptor gene (ADORA2A) variants may increase autistic symptoms and anxiety in autism spectrum disorder.
Freitag CM
European Child & Adolescent Psychiatry, 19(1), 67-74 (2010)
[Adenosine A2A receptor as a drug target for treatment of sepsis]
Sivak KV, et al.
Molekuliarnaia Biologiia, 50(2), 231-245 (2016)
A genetic variation in the ADORA2A gene modifies age at onset in Huntington's disease
Dhaenens CM, et al.
Neurobiology of Disease, 35(3), 474-476 (2009)

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