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SAB4200039

Sigma-Aldrich

Anti-Serotonin Transporter (N-terminal) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-5-hydroxytryptamine transporter, Anti-5HTT, Anti-HTT, Anti-OCD1, Anti-SERT, Anti-SLC6A4 solute carrier family 6, member 4

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~83 kDa

species reactivity

human

concentration

~1.5 mg/mL

technique(s)

western blot: 1.5-3.0 μg/mL using SH-SY5Y cell lysates

UniProt accession no.

P31645

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

rat ... Slc6a4(25553)

General description

Solute carrier family 6 member 4 (SLC6A4), also known as 5-hydroxytryptamine transporter (5-HTT), is an integral membrane protein, encoded by the gene mapped to human chromosome 17q11.2. The encoded protein is a member of SLC6 gene family and is mainly expressed in brain and blood cells.

Application

Anti-Serotonin Transporter (N-terminal) antibody produced in rabbit has been used in western blot analysis and immunohistochemistry.

Biochem/physiol Actions

Solute carrier family 6 member 4 (SLC6A4) catalyzes the transport of neurotransmitter serotonin from the synaptic space into presynaptic neurons. It also plays a vital role in mood and anxiety regulation. Mutation on the gene might alter the expression of serotonin (5HT) in the synaptic cleft, which ultimately leads to schizophrenia. Allelic variations in the gene increases the risk of susceptibility to autism and rigid-compulsive behaviors.
The polymorphic promoter region of the serotonin transporter gene serotonin-transporter-linked polymorphic region (5HTTLPR), has been suggested to affect serotonin uptake and may play a role in the pathogenesis of depression, obsessive-compulsive disorder (OCD) and aggressive behavior.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Elevation of cortical serotonin transporter activity upon peripheral immune challenge is regulated independently of p38 mitogen-activated protein kinase activation and transporter phosphorylation.
Schwamborn R, et.al.
Journal of Neurochemistry, 137, 423-435 (2016)
Epigenetic changes of serotonin transporter in the patients with alcohol dependence: methylation of an serotonin transporter promoter CpG island.
Park BY
Psychiatry Investigation, 8, 130-133 (2011)
Mahesh Mundalil Vasu et al.
PloS one, 11(10), e0164425-e0164425 (2016-10-08)
Evidence suggests neuroprotective effects of fluoxetine, a selective serotonin reuptake inhibitor (SSRI), on the developed neurons in the adult brain. In contrast, the drug may be deleterious to immature or undifferentiated neural cells, although the mechanism is unclear. Recent investigations
Mariko Nakamura et al.
Human psychopharmacology, 37(2), e2818-e2818 (2021-09-21)
The aim of this study was evaluation of the association between severity of pain and expression of total or ubiquitinated serotonin transporter (SERT) protein in patients with burning mouth syndrome and atypical odontalgia (BMS/AO), who were treated by duloxetine. Patients
Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors.
Sutcliffe JS
American Journal of Human Genetics, 77, 265-279 (2005)
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