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E8886

Sigma-Aldrich

Erythrosin extra bluish

Dye content, ≥80%, certified by the Biological Stain Commission, powder

Synonym(s):

2′,4′,5′,7′-Tetraiodofluorescein disodium salt, Acid Red 51, Iodoeosin

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About This Item

Empirical Formula (Hill Notation):
C20H6I4Na2O5
CAS Number:
16423-68-0
Molecular Weight:
879.86
Colour Index Number:
45430
Beilstein:
1443945
EC Number:
240-474-8
MDL number:
MFCD00144257
UNSPSC Code:
12171500
PubChem Substance ID:
24894685
NACRES:
NA.47

product name

Erythrosin extra bluish, certified by the Biological Stain Commission

grade

certified by the Biological Stain Commission

form

powder

composition

Dye content, ≥80%

pH

6.4 (30.3 °C)

mp

315 °C

solubility

water: 1 mg/mL, clear

density

0.625-0.731 g/cm3 at 30.1 °C

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[Na+].[Na+].[O-]c1c(I)cc2c(Oc3c(I)c([O-])c(I)cc3C24OC(=O)c5ccccc45)c1I

InChI

1S/C20H8I4O5.2Na/c21-11-5-9-17(13(23)15(11)25)28-18-10(6-12(22)16(26)14(18)24)20(9)8-4-2-1-3-7(8)19(27)29-20;;/h1-6,25-26H;;/q;2*+1/p-2

InChI key

RAGZEDHHTPQLAI-UHFFFAOYSA-L

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General description

Erythrosin extra bluish is soluble in ethanol and water. It is a brown powder, with a pH range of 2.5 to 4. It is used in color filters, light emitting diodes, cosmetics and hair dyes. It has been used in many biological applications such as, detecting gene expression, treating age related macular degeneration, diabetes and obesity.

Suitability

Certified for use in the Jackson stain for plant anatomy; counterstain for alum hematoxylin; Kreyberg′s method for keratin and mucus.

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H302,H411

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

359.6 °F - closed cup

Flash Point(C)

182 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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R W Sabnis.
Handbook of Biological Dyes and Stains: Synthesis and Industrial Applications, 544-544 (2010)
R W Sabnis.
Handbook of Acid-Base Indicators (2007)
Vagner Roberto Batistela et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 79(5), 889-897 (2011-05-10)
Xanthenes form to an important class of dyes which are widely used. Most of them present three acid-base groups: two phenolic sites and one carboxylic site. Therefore, the pKa determination and the attribution of each group to the corresponding pKa
Farah Maria Drumond Chequer et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(10), 3447-3451 (2012-08-01)
Erythrosine (ErB) is a xanthene and an US Food and Drug Administration approved dye used in foods, drugs and cosmetics. Although its utilization is permitted, ErB is described as inhibitor of enzymes and protein-protein interactions and is toxic to pituitary
H Edward Wong et al.
PloS one, 6(10), e25752-e25752 (2011-10-15)
Alzheimer's disease (AD) is the most common form of dementia. AD is a degenerative brain disorder that causes problems with memory, thinking and behavior. It has been suggested that aggregation of amyloid-beta peptide (Aβ) is closely linked to the development
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