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C4428

Cathepsin G from human leukocytes

lyophilized powder, ≥60 units/mg protein (Bradford)

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About This Item

CAS Number:
107200-92-0
EC Number:
3.4.21.20 (BRENDA, IUBMB)
UNSPSC Code:
12352200
NACRES:
NA.32
MDL number:
MFCD00130750
Specific activity:
≥60 units/mg protein (Bradford)
Biological source:
human leucocytes
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biological source

human leucocytes

Quality Level

200

form

lyophilized powder

specific activity

≥60 units/mg protein (Bradford)

mol wt

23-30 kDa

UniProt accession no.

P08311

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... CTSG(1511)

General description

Cathepsin G from human leukocytes is a neutral proteinase secreted by neutrophil granulocytes. It belongs to the family of serine proteases. Cathepsin G is a glycoprotein, which contains 1% carbohydrate. The gene is located on human chromosome 14q12.

Application

Cathepsin G from human leukocytes has been used to determine protease sensitivity. It has also been used for the stimulation and staining of dendritic cells and macrophage.

Biochem/physiol Actions

Cathepsin G has pro-apoptotic activity and can activate caspases in vitro.
Cathepsin G from human leukocytes degrades various proteins, such as elastin, collagen, fibrinogen and immunoglobin. It may be implicated in muscle catabolism. Cathepsin G is involved in the activation or inactivation of protein hormones and the inactivation of plasma proteinase inhibitors. It alters the cytoskeleton, enhances the permeability of vascular endothelial cells and the chemotaxis of inflammatory cells. Cathepsin G is associated with autoimmunity and cancer. It exhibits chymotrypsin and trypsin like activity. Cathepsin G modulates neutrophil effector functions.

Physical form

Lyophilized from 0.5 M pyridinium acetate, pH 5.3.

Other Notes

One unit will release one nanomole of p-nitroaniline per second from N-succinyl-Ala-Ala-Pro-Phe p-nitroanilide at pH 7.5 at 37 °C.

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This Item
219373C6854C8571
Cathepsin G from human leukocytes lyophilized powder, ≥60 units/mg protein (Bradford)

Sigma-Aldrich

C4428

Cathepsin G from human leukocytes

Cathepsin G, Human Neutrophil Cathepsin G, Human Neutrophil, CAS 107200-92-0, is a purified native cathepsin G. Acts as a potent agonist of human platelet activation leading to their aggregation.

Sigma-Aldrich

219373

Cathepsin G, Human Neutrophil

Cathepsin L from human liver ≥0.5 units/mg protein, solution

Sigma-Aldrich

C6854

Cathepsin L from human liver

Cathepsin B from human liver buffered aqueous solution, ≥200 units/mg protein (One unit is defined as the amount of enzyme that hydrolyzes 1 μmol of Z-Arg-Arg-beta-naphthylamide per minute at 40 °C, using 100 mM Na/K phosphate, pH 6.0, with 1.33 mM EDTA and 2 mM DTT as the activation buffer.)

Sigma-Aldrich

C8571

Cathepsin B from human liver

Gene Information

human ... CTSG(1511)

Gene Information

human ... CTSG(1511)

Gene Information

human ... CTSL1(1514)

Gene Information

human ... CTSB(1508)

specific activity

≥60 units/mg protein (Bradford)

specific activity

≥2 units/mg protein

specific activity

≥0.5 units/mg protein

specific activity

≥200 units/mg protein (One unit is defined as the amount of enzyme that hydrolyzes 1 μmol of Z-Arg-Arg-beta-naphthylamide per minute at 40 °C, using 100 mM Na/K phosphate, pH 6.0, with 1.33 mM EDTA and 2 mM DTT as the activation buffer.)

biological source

human leucocytes

biological source

human neutrophils

biological source

human liver

biological source

human liver

form

lyophilized powder

form

lyophilized solid (Salt-free)

form

solution

form

buffered aqueous solution

shipped in

dry ice

shipped in

ambient

shipped in

dry ice

shipped in

dry ice

UniProt accession no.

P08311

UniProt accession no.

-

UniProt accession no.

P07711

UniProt accession no.

P07858

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
SLCQ4000
SLCQ4000
SLCK7267
SLCF4556
SLBX8158

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Related Content

Product Information Sheet - C4428

Product Information Sheet

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Global Trade Item Number

SKUGTIN
C4428-.25UN04061833618738

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