The potency of this material is not determined on a lot to lot basis. However, historical data indicate potency values of >900 ug/mg.
A3650
Amikacin hydrate
aminoglycoside antibiotic
Synonym(s):
N1-[(S)-4-Amino-2-hydroxybutyryl]kanamycin A
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About This Item
Empirical Formula (Hill Notation):
C22H43N5O13 · xH2O
CAS Number:
Molecular Weight:
585.60 (anhydrous basis)
UNSPSC Code:
51281632
NACRES:
NA.85
PubChem Substance ID:
EC Number:
253-538-5
Beilstein/REAXYS Number:
1445422
MDL number:
Pricing and availability is not currently available.
biological source
synthetic
Quality Level
form
powder
color
white to almost white
antibiotic activity spectrum
Gram-negative bacteria, mycobacteria
mode of action
protein synthesis | interferes
storage temp.
2-8°C
SMILES string
O.NCC[C@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O
InChI
1S/C22H43N5O13.H2O/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);1H2/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;/m0./s1
InChI key
DTSOZYYWEZJFSS-XTHCGPPUSA-N
General description
Chemical structure: aminoglycoside
Application
Biochem/physiol Actions
Amikacin inhibits bacterial protein synthesis by binding to the 30S ribosome subunit and inducing mRNA misreading. It interferes with the translocation of tRNA from the A-site to the P-site.[3]
Packaging
5G
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
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This Item | |||
|---|---|---|---|
| antibiotic activity spectrum Gram-negative bacteria, mycobacteria | antibiotic activity spectrum Gram-negative bacteria, mycobacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria, mycobacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria, mycoplasma |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form powder | form powder or crystals | form powder | form powder or crystals |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C |
| biological source synthetic | biological source synthetic | biological source synthetic | biological source - |
| color white to almost white | color white to off-white | color white to off-white | color - |
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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H W Horowitz et al.
Antimicrobial agents and chemotherapy, 45(3), 786-788 (2001-02-22)
Human granulocytic ehrlichiosis is a recently described disease caused by an obligate intracellular gram-negative organism recently named Ehrlichia phagocytophila. To expand our knowledge of the susceptibility of E. phagocytophila, we tested six New York State isolates for susceptibility to 12
G J Alangaden et al.
Antimicrobial agents and chemotherapy, 42(5), 1295-1297 (1998-05-21)
An A1400G mutation of the rrs gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical isolates resistant to amikacin-kanamycin (MICs, >128 microg/ml). High-level cross-resistance may result from such a mutation since MTB has a
M P Goren et al.
The Pediatric infectious disease journal, 8(5), 278-282 (1989-05-01)
A three-drug antibiotic regimen including vancomycin and amikacin has been recommended as effective treatment in clinical settings in which Gram-positive bacteremias are a serious problem. To determine if vancomycin potentiates the tubular proteinuria associated with amikacin therapy, we studied febrile
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A3650-5G | 04061835542055 |
| A3650-250MG | 04061833433287 |
| A3650-1G | 04061824071078 |
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where can i find the assay potency of the drug?
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