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880530C

Avanti

18:1 PEG550 PE

Avanti Research™ - A Croda Brand 880530C

Synonym(s):

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-550] (ammonium salt)

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About This Item

CAS Number:
474922-90-2
UNSPSC Code:
12352211
NACRES:
NA.25

form

liquid

packaging

pkg of 1 × 2.5 mL (880530C-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 880530C

concentration

10 mg/mL (880530C-25mg)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCCNC(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+]

General description

18:1 PEG550 PE is a polyethylene glycol (PEG) conjugated phospholipid. PEGylated phospholipids are amphiphilic polymers, The molecular weight and exact mass are averages based on the polydispersity of PEG.

Application

18:1 PEG550 PE is suitable for liposome formation.

Biochem/physiol Actions

The use of 18:1 PEG550 PE in liposomes reduces the random binding of quantum dot tagged proteins to the lipid bilayer. Polyethylene glycol (PEG) conjugated phospholipids are known to protect the steric nature of liposomes. Hence, they are commonly recommended for use in liposome formulation. PEGylated lipids are used as drug carriers. Use of highly concentrated PEG-lipids makes the possibility of mixed micelles.

Packaging

5 mL Clear Glass Sealed Ampule (880530C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system

WGK

WGK 3

Certificates of Analysis (COA)

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Micro- and Nanoengineering of the Cell Surface (2014)
Teresa Fazio et al.
Langmuir : the ACS journal of surfaces and colloids, 24(18), 10524-10531 (2008-08-08)
Single molecule visualization of protein-DNA complexes can reveal details of reaction mechanisms and macromolecular dynamics inaccessible to traditional biochemical assays. However, these techniques are often limited by the inherent difficulty of collecting statistically relevant information from experiments explicitly designed to
Brian J Nablo et al.
Biophysical journal, 95(3), 1157-1164 (2008-07-23)
Nonelectrolyte polymers of poly(ethylene glycol) (PEG) were used to estimate the diameter of the ion channel formed by the Bacillus anthracis protective antigen 63 (PA(63)). Based on the ability of different molecular weight PEGs to partition into the pore and
Maria C Sandström et al.
Langmuir : the ACS journal of surfaces and colloids, 23(8), 4192-4198 (2007-03-09)
Polyethylene glycol (PEG)-conjugated lipids are commonly employed for steric stabilization of liposomes. When added in high concentrations PEG-lipids induce formation of mixed micelles, and depending on the lipid composition of the sample, these may adapt either a discoidal or a
G F Peacock et al.
Drug delivery, 10(1), 29-34 (2003-01-30)
A new cholesterol-carborane conjugate (BCH) has been synthesized as a potential targeting agent for boron neutron capture therapy (BNCT) of cancers. The compound is extremely water insoluble and was formulated in two liposomal formulations to determine if the compound could
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