P3252
6-Phenyl-2-thiouracil
≥95%
Synonym(s):
2-Mercapto-6-phenyl pyrimidine-4-ol, 6-Phenylthiouracil, Fenucil
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About This Item
Empirical Formula (Hill Notation):
C10H8N2OS
CAS Number:
Molecular Weight:
204.25
EC Number:
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
Recommended Products
biological source
synthetic (organic)
Quality Level
Assay
≥95%
form
powder
solubility
DMF: 20 mg/mL, clear to slightly hazy, colorless to light yellow
SMILES string
Oc1cc(nc(S)n1)-c2ccccc2
InChI
1S/C10H8N2OS/c13-9-6-8(11-10(14)12-9)7-4-2-1-3-5-7/h1-6H,(H2,11,12,13,14)
InChI key
XEKNACRTWJHOCE-UHFFFAOYSA-N
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Application
6-Phenyl-2-thiouracil is a thyreostatic (thyroid hormone) agent that may be used as a reference material in thyreostatic drug separation and detection technologies such as capillary electrophoresis, HPLC, or gas chromatography.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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S Abuín et al.
Analytica chimica acta, 617(1-2), 184-191 (2008-05-20)
A method based on ultra-performance liquid chromatography-electrospray ionisation-tandem mass spectrometry for the determination of six thyreostatic drugs in thyroid tissue has been optimised and validated in accordance with the Decision 2002/657/EC. Samples are extracted with methanol and the extracts cleaned-up
Highly potent and selective inhibition of HIV-1 replication by 6-phenylthiouracil derivatives.
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Tomás Pérez-Ruiz et al.
Electrophoresis, 26(12), 2384-2390 (2005-05-17)
This paper reports the development of a method based on capillary electrophoresis with laser-induced fluorescence detection for the simultaneous determination of thiouracil (TU) and phenylthiouracil (PhTU) with high sensitivity (nanomolar range, i.e., attomoles detected). After derivatization with 5-iodoacetamidofluorescein, the analytes
Dexian Kong et al.
Electrophoresis, 30(19), 3489-3495 (2009-09-04)
A simple, rapid, reproducible and sensitive method based on CE with electrochemical detector was developed for the simultaneous determination of five thyreostatics including 2-thiouracil (TU), 6-methyl-2-thiouracil (MTU), 6-propyl-2-thiouracil (PTU), 6-phenyl-2-thiouracil (PhTU) and methimazole (TAP) in animal feeds. A home-made wall-jet
Yuan Liu et al.
Rapid communications in mass spectrometry : RCM, 21(9), 1504-1510 (2007-03-31)
A novel approach for determination of 2-mercaptobenzimidazole (MBI) and other thyreostatic residues in animal tissues by gas chromatography/mass spectrometry (GC/MS) in selected ion monitoring mode was developed. The analytes in animal tissues (including hypothyroid, pork muscle and beef samples) were
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