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I3636

Sigma-Aldrich

Acridine Mutagen ICR 191

Synonym(s):

6-Chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C19H21Cl2N3O · 2HCl
CAS Number:
17070-45-0
Molecular Weight:
451.22
Beilstein:
8176205
EC Number:
241-129-4
MDL number:
MFCD00013320
UNSPSC Code:
12171500
PubChem Substance ID:
24896042
NACRES:
NA.32

solubility

DMSO: soluble

Quality Level

200

suitability

suitable for Ames test in Salmonella and E. coli (Frameshift mutagenic standard)

storage temp.

2-8°C

SMILES string

Cl[H].Cl[H].COc1ccc2nc3cc(Cl)ccc3c(NCCCNCCCl)c2c1

InChI

1S/C19H21Cl2N3O.2ClH/c1-25-14-4-6-17-16(12-14)19(23-9-2-8-22-10-7-20)15-5-3-13(21)11-18(15)24-17;;/h3-6,11-12,22H,2,7-10H2,1H3,(H,23,24);2*1H

InChI key

LMEMIKWTNPWYMI-UHFFFAOYSA-N

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Related Categories

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H300 + H310 + H330,H350

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Carc. 1B

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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M Watanabe et al.
Mutation research, 314(1), 27-37 (1994-01-01)
The specificity of frameshift mutations induced by several classes of chemical mutagens was determined using a collection of mutant E. coli lacZ genes. This collection can detect each of five kinds of specific frameshift events by scoring Lac+ revertant colonies.
R McKendry et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(24), 11455-11459 (1991-12-15)
2fTGH is a human cell line containing the selectable marker guanine phosphoribosyltransferase regulated by alpha interferon (IFN-alpha). Two IFN-alpha-unresponsive mutants were isolated previously at a low frequency (ca. 10(-8)) by selecting mutagenized 2fTGH cells in selective medium containing 6-thioguanine and
Kathryn Annett et al.
Experimental gerontology, 40(12), 976-981 (2005-10-12)
T cells undergo rapid clonal expansion upon antigenic stimulation to produce an effective immune response. Any defect in the DNA mismatch repair (MMR) system may have a detrimental effect on T cell proliferation. This study employed an in vitro model
K F Kiser et al.
Oncogene, 25(50), 6595-6603 (2006-05-17)
Retroviral integration mutagenesis and treatment with the frameshift mutagen ICR191 were used to transform v-H-ras expressing PB-3c cells to interleukin-3 (IL-3) independence. Six clones displayed viral integrations into the 3' region of the IL-3 gene thus acting post-transcriptionally by disrupting
Katerina Vlasakova et al.
Mutation research, 578(1-2), 225-237 (2005-09-07)
A novel forward mutation assay has been developed in Salmonella typhimurium based on resistance to 5-fluorouracil (FU). The mutational target in the FU assay was determined to be the uracil phosphoribosyl transferase (upp) gene. To validate the upp gene as
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