495455

Oligomycin

≥90% (mixture of A, B, and C isomers, HPLC), powder, Antibiotic, Calbiochem

• Synonym(s): Oligomycin
• Empirical Formula (Hill Notation): C₄₅H₇₄O₁₁
• CAS Number: 1404-19-9
• Molecular Weight: 791.06
• MDL number: MFCD01779388
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Product Name: Oligomycin, A mixture of A, B, and C isomers.
• Quality Level: 100
• Assay: ≥90% (mixture of A, B, and C isomers, HPLC)
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13+,17-15-,21-18+
• InChI key: MNULEGDCPYONBU-ZUSSGZTJSA-N

Description

General description

A mixture of A, B, and C isomers. A macrolide antibiotic that inhibits membrane-bound mitochondrial ATP synthase, preventing phosphoryl group transfer. Induces apoptosis in cultured human lymphoblastoid and other mammalian cells.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Membrane-bound mitochondrial ATPase (F1)

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 2 months at -20°C.

Other Notes

Wolvetang, E.J., et al. 1994. FEBS Lett.339, 40.
Amoroso, S., et al. 1993. J. Pharmacol. Exp. Ther.264, 515.
Brustovetsky, N.N., et al. 1993. FEBS Lett.315, 233.
Nagamune, H., et al. 1993. Biochim. Biophys. Acta1141, 231.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable