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Sigma-Aldrich

Poly[(R)-3-hydroxybutyric acid]

natural origin

Synonym(s):

(R)-3-Hydroxybutyric acid polymerized, PHB

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About This Item

Linear Formula:
[COCH2CH(CH3)O]n
CAS Number:
29435-48-1
MDL number:
MFCD00134263
UNSPSC Code:
12162002
PubChem Substance ID:
24862200
NACRES:
NA.23

Quality Level

200

transition temp

Tm 172 °C (DSC)

SMILES string

CC(O)CC(O)=O

InChI

1S/C12H20O6/c1-8(14)6-11(15)18-10(3)7-12(16)17-9(2)4-5-13/h5,8-10,14H,4,6-7H2,1-3H3

InChI key

QLACRIKFZRFWRU-UHFFFAOYSA-N

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General description

Biocompatible, biodegradable polymer.

Application

Poly[(R)-3-hydroxybutyric acid (PHB) is a biodegradable and biocompatible polymer produced by several bacterial species, owing to its low resorbability and tunable properties, it may find uses in a variety of applications such as tissue engineering, controlled release systems etc.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Proliferation and skeletal myotube formation capability of C2C12 and H9c2 cells on isotropic and anisotropic electrospun nanofibrous PHB scaffolds.
Ricotti L, et al.
Biomedical Materials (Bristol, England), 7(3), 035010-035010 (2012)
Engineering of Saccharomyces cerevisiae for the production of poly-3-d-hydroxybutyrate from xylose.
Sandstrom A G, et al.
AMB Express, 5(1), 14-14 (2015)
Molecular mass of poly [(R)-3-hydroxybutyric acid] produced in a recombinant Escherichia coli.
Kusaka S, et al.
Applied Microbiology and Biotechnology, 47(2), 140-143 (1997)
Tarek M Madkour et al.
Physical chemistry chemical physics : PCCP, 15(16), 5982-5991 (2013-03-16)
To fully understand the thermodynamic nature of polymer blends and accurately predict their miscibility on a microscopic level, a hybrid model employing both statistical mechanics and molecular dynamics techniques was developed to effectively predict the total free energy of mixing.
Pia Elustondo et al.
Chemistry & biodiversity, 9(11), 2597-2604 (2012-11-20)
Poly-3-hydroxybutyrate (PHB) is a biological polyester present in bacteria and eukaryotic cells. Long-chain (or storage) sPHB (up to 100,000 residues) is typically present in PHB-accumulating bacteria and localized in specialized granules known as carbonosomes. In these organisms, sPHB plays a
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