G6264
Guanosine
BioReagent, suitable for cell culture
Synonym(s):
9-(β-D-Ribofuranosyl)guanine, Guanine-9-β-D-ribofuranoside
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All Photos(3)
About This Item
Empirical Formula (Hill Notation):
C10H13N5O5
CAS Number:
Molecular Weight:
283.24
Beilstein:
625911
EC Number:
MDL number:
UNSPSC Code:
12352205
PubChem Substance ID:
NACRES:
NA.75
Pricing and availability is not currently available.
Recommended Products
biological source
synthetic
Quality Level
product line
BioReagent
Assay
≥98%
form
powder
technique(s)
cell culture | mammalian: suitable
mp
250 °C (dec.) (lit.)
solubility
0.05 M acetic acid: 1 mg/mL, clear, colorless
shipped in
ambient
storage temp.
room temp
SMILES string
[H]O[H].NC1=Nc2c(ncn2[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C(=O)N1
InChI
1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1
InChI key
NYHBQMYGNKIUIF-UUOKFMHZSA-N
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Application
Guanosine has been used:
- as a ribonucleoside component of the basal medium to study its effects on Bacillus mojavensis′s anaerobic growth
- as a component of the Dulbecco′s modified Eagle medium (DMEM) to culture mouse-derived embryonic stem cells
- as a component of the nucleoside solution to culture chicken embryonic stem cells
Biochem/physiol Actions
Guanosine is a purine nucleoside that exhibits important functions in cell metabolism. It has also shown neuroprotective and neurotrophic effects in glial cells, hippocampal neurons, and pheochromocytoma cells by inducing proliferation and differentiation and also exerting anti-apoptotic effects. Guanosine acts as a therapeutic agent against several neuropathologies. It exerts its effects against sepsis-induced cognitive impairment, hepatic encephalopathy, lipopolysaccharide (LPS)-induced inflammation, ischemic injury, and azide-induced oxidative damage. Guanosine is suitable for use in cell culture applications as a precursor of guanosine monophosphate (GMP), guanosine diphosphate (GDP), guanosine triphosphate (GTP), and cyclic GMP (cGMP).
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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