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  • Manuka Honey Induces Apoptosis of Epithelial Cancer Cells through Aquaporin-3 and Calcium Signaling.

Manuka Honey Induces Apoptosis of Epithelial Cancer Cells through Aquaporin-3 and Calcium Signaling.

Life (Basel, Switzerland) (2020-10-31)
Simona Martinotti, Giorgia Pellavio, Mauro Patrone, Umberto Laforenza, Elia Ranzato
ABSTRACT

Honey is a natural product with a long use in traditional medicine and is well recognized to regulate different biological events. It is an important source of various biological or pharmacological molecules and, therefore, there is a strong interest to explore their properties. Evidence is growing that honey may have the potential to be an anticancer agent acting through several mechanisms. Here we observed for the first time in a cancer cell line a possible mechanism through which honey could induce an alteration in the intracellular reactive oxygen species and homeostatic balance of intracellular calcium concentration leading to cell death by apoptosis. This mechanism seems to be enhanced by manuka honey's ability to maintain high H2O2 permeability through aquaporin-3.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Anti-AQP3 antibody produced in rabbit, 1 mg/mL, affinity isolated antibody
Sigma-Aldrich
Goat Anti-Rabbit IgG Antibody, Peroxidase Conjugated, 1 mg/mL (after reconstitution), Chemicon®