T7665

Tyrphostin 51

≥98%

• Synonym(s): 2-Amino-1,1,3-tricyano-4-(3′,4′,5′-trihydroxyphenyl)butadiene
• Empirical Formula (Hill Notation): C₁₃H₈N₄O₃
• CAS Number: 126433-07-6
• Molecular Weight: 268.23
• NACRES: NA.77
• PubChem Substance ID: 24278756
• UNSPSC Code: 12352200
• MDL number: MFCD00133903
• Assay: ≥98%
• Form: powder

Properties

• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥98%
• form: powder
• potency: 0.8 μM IC₅₀
• solubility: DMSO: soluble 5 mg of Tyrphostin 51 in 0.1 ml of solvent, clear, orange to red
• storage temp.: 2-8°C
• SMILES string: NC(\C(=C\c1cc(O)c(O)c(O)c1)C#N)=C(/C#N)C#N
• InChI: 1S/C13H8N4O3/c14-4-8(12(17)9(5-15)6-16)1-7-2-10(18)13(20)11(19)3-7/h1-3,18-20H,17H2/b8-1+
• InChI key: JKNOYWVMHPMBEL-UNXLUWIOSA-N
• Gene Information: human ... CDK2(1017), EGFR(1956)

Description

Application

Tyrphostin 51 has been used to study the inhibition of rat hepatic leptin 1[1].

Biochem/physiol Actions

EGFR tyrosine kinase inhibitor.

Tyrphostin 51 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain[2],[3].

Features and Benefits

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Preparation Note

5 mg of Tyrphostin 51 is soluble in 0.1 ml of DMSO and yields a clear, orange to red solution.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)