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SML2185

Sigma-Aldrich

PA-6

≥98% (HPLC)

Synonym(s):

1,5-Bis[4-[[imino(phenyl)methyl]amino]phenoxy]pentane, N,N′-[1,5-Pentanediylbis(oxy-4,1-phenylene)]bis-benzenecarboximidamide, Pentamidine-Analogue 6

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About This Item

Empirical Formula (Hill Notation):
C31H32N4O2
CAS Number:
500715-03-7
Molecular Weight:
492.61
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

N=C(C1=CC=CC=C1)NC(C=C2)=CC=C2OCCCCCOC3=CC=C(NC(C4=CC=CC=C4)=N)C=C3

Biochem/physiol Actions

PA-6 (Pentamidine-Analogue 6) is a selective and potent IK1 (inward rectifier potassium current) inhibitor that terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models. PA-6 interacts with the cytoplasmic pore region of the KIR2.1 (KCNJ2) ion channel.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hiroki Takanari et al.
Cardiovascular research, 99(1), 203-214 (2013-04-30)
In excitable cells, KIR2.x ion-channel-carried inward rectifier current (IK₁) is thought to set the negative and stable resting membrane potential, and contributes to action potential repolarization. Loss- or gain-of-function mutations correlate with cardiac arrhythmias and pathological remodelling affects normal KIR2.x
Yuan Ji et al.
Journal of biomedical science, 24(1), 44-44 (2017-07-18)
The inward rectifier potassium current IK1 contributes to a stable resting membrane potential and phase 3 repolarization of the cardiac action potential. KCNJ2 gain-of-function mutations V93I and D172N associate with increased IK1, short QT syndrome type 3 and congenital atrial
Yuan Ji et al.
British journal of pharmacology, 174(15), 2576-2590 (2017-05-26)
The density of the inward rectifier current (IK1 ) increases in atrial fibrillation (AF), shortening effective refractory period and thus promoting atrial re-entry. The synthetic compound pentamidine analogue 6 (PA-6) is a selective and potent IK1 inhibitor. We tested PA-6
Christophe Gattlen et al.
Glia, 68(10), 2119-2135 (2020-03-29)
Spinal microglia change their phenotype and proliferate after nerve injury, contributing to neuropathic pain. For the first time, we have characterized the electrophysiological properties of microglia and the potential role of microglial potassium channels in the spared nerve injury (SNI)

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