SML1353

ML351

≥98% (HPLC)

• Synonym(s): 5-(Methylamino)-2-(1-naphthalenyl)-4-oxazolecarbonitrile, CID 664510, ML 351, SID 104223766
• Empirical Formula (Hill Notation): C₁₅H₁₁N₃O
• CAS Number: 847163-28-4
• Molecular Weight: 249.27
• NACRES: NA.77
• PubChem Substance ID: 329825808
• UNSPSC Code: 12352200
• MDL number: MFCD04183120
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CNC1=C(C#N)N=C(O1)C2=C3C(C=CC=C3)=CC=C2
• InChI: 1S/C15H11N3O/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,17H,1H3
• InChI key: DYXYXTDIFMDJIR-UHFFFAOYSA-N

Description

Biochem/physiol Actions

ML351 is a cell penetrant, selective and highly potent human lipoxygenase-12/15 (15-Lipoxygenase-1, 12/15-LOX) inhibitor that exhibits protective effects against oxidative glutamate toxicity in mouse neuronal HT22 cells. ML351 reduces infarct size in a mouse model of ischemic stroke.

ML351 is a cell penetrant, selective and highly potent human lipoxygenase-12/15 (15-Lipoxygenase-1, 12/15-LOX) inhibitor.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable