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SC79

Name: SC79
Brand: SIGMA

≥97% (NMR), AKT activator, powder

Synonym(s):

2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₇ClN₂O₅

CAS Number:

305834-79-1

Molecular Weight:

364.78

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥97% (NMR)

Form:

powder

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Properties

Product Name

SC79, ≥97% (NMR)

Quality Segment

100

assay

≥97% (NMR)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

Clc1cc2c(cc1)OC(=C(C2C(C(=O)OCC)C#N)C(=O)OCC)N

InChI

1S/C17H17ClN2O5/c1-3-23-16(21)11(8-19)13-10-7-9(18)5-6-12(10)25-15(20)14(13)17(22)24-4-2/h5-7,11,13H,3-4,20H2,1-2H3

InChI key

DXVKFBGVVRSOLI-UHFFFAOYSA-N

Description

Application

SC79 has been used in western blot analysis as a positive control to measure the extent of phosphorylation of Akt and also to activate Akt that has been suppressed by nitidine chloride, a natural bioactive alkaloid.

Biochem/physiol Actions

SC79 is an AKT activator.

SC79 is an AKT activator. SC79 binds to the plecktrin homology (PH) domain of Akt that mimics the binding of PtdIns(3,4,5)P3 to induce a conformational change in Akt that enhances phosphorylation and activation. SC79 induces cytosolic Akt signaling in cell based assays, and prevents neuronal death in a mouse model of stroke.

Features and Benefits

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item	123871	124009	124008
Sigma-Aldrich SML0749 SC79	Sigma-Aldrich 123871 Akt Activator II, SC79	Sigma-Aldrich 124009 Akt Inhibitor III	Sigma-Aldrich 124008 Akt Inhibitor II
description ≥97% (NMR)	description Akt Activator II, SC79, CAS 305834-79-1, is a cell-permeable compound that interacts with Akt PH domain PIP3 binding pocket and makes it more susceptible to phosphorylation by upstream Kinases.	description The Akt Inhibitor III controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.	description The Akt Inhibitor II controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
assay ≥97% (NMR)	assay ≥98% (sum of two isomers, HPLC)	assay ≥98% (NMR)	assay ≥98% (NMR)
form powder	form solid	form solid	form solid
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
solubility DMSO: 20 mg/mL, clear	solubility DMSO: 50 mg/mL	solubility DMSO: 10 mg/mL	solubility DMSO: 10 mg/mL
color white to beige	color off-white	color white	color white

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Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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