SML0345

A 887826

≥98% (HPLC)

• Synonym(s): 5-(4-butoxy-3-chlorophenyl)-N-[[2-(4-morpholinyl)-3-pyridinyl]methyl]-3-pyridinecarboxamide
• Empirical Formula (Hill Notation): C₂₆H₂₉ClN₄O₃
• CAS Number: 1266212-81-0
• Molecular Weight: 480.99
• NACRES: NA.77
• PubChem Substance ID: 329825349
• UNSPSC Code: 12352200
• MDL number: MFCD20926345
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: ≥5 mg/mL
• storage temp.: 2-8°C
• SMILES string: CCCCOc1ccc(cc1Cl)-c2cncc(c2)C(=O)NCc3cccnc3N4CCOCC4
• InChI: 1S/C26H29ClN4O3/c1-2-3-11-34-24-7-6-19(15-23(24)27)21-14-22(17-28-16-21)26(32)30-18-20-5-4-8-29-25(20)31-9-12-33-13-10-31/h4-8,14-17H,2-3,9-13,18H2,1H3,(H,30,32)
• InChI key: JPJGFWKHSMUKFO-UHFFFAOYSA-N

Description

Biochem/physiol Actions

A-887826 is Nav1.8 channel blocker (IC₅₀ = 11 nM) that blocks TTX-resistant sodium currents in rat dorsal root ganglion in a voltage dependent fashion. Oral administration of A-887826 to rats significantly attenuated tactile allodynia in a neuropathic pain model.

Nav1.8 channel blocker

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable