SML0202

DPH

≥98% (HPLC)

• Synonym(s): 5-(1,3-diaryl-1H-pyrazol-4-yl)hydantoin, 5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]-2,4-imidazolidinedione
• Empirical Formula (Hill Notation): C₁₈H₁₃FN₄O₂
• CAS Number: 484049-04-9
• Molecular Weight: 336.32
• NACRES: NA.77
• PubChem Substance ID: 329825226
• UNSPSC Code: 12352200
• MDL number: MFCD03268950
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: ≥10 mg/mL
• storage temp.: 2-8°C
• SMILES string: Fc1ccc(cc1)-c2nn(cc2C3NC(=O)NC3=O)-c4ccccc4
• InChI: 1S/C18H13FN4O2/c19-12-8-6-11(7-9-12)15-14(16-17(24)21-18(25)20-16)10-23(22-15)13-4-2-1-3-5-13/h1-10,16H,(H2,20,21,24,25)
• InChI key: MPQWYPLPWGUMJE-UHFFFAOYSA-N

Description

Application

DPH may be used in c-Abl tyrosine kinase-mediated cell signaling studies.

Biochem/physiol Actions

DPH binds and alters the conformation of the myristoyl binding site of c-Abl tyrosine kinase. It exhibits potent enzymatic and cellular activity that stimulates the activation of c-Abl.

DPH is a potent cell permeable c-Abl activator. DPH binds to the myristoyl binding site and leads to activation of c-Abl kinase activity. The compound stimulates the phosphorylation of c-Abl and its downstream substrate Crk.

Potent cell permeable c-Abl activator

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Abl page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable