SAB2500438

Anti-G6PD (AA 308-320) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-G6PD1, Anti-Glucose-6-phosphate dehydrogenase
• MDL number: MFCD00162329
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: goat
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: canine, rat, mouse, human
• technique(s): immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• UniProt accession no.: P11413
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... G6PD(2539)

Description

General description

The gene encoding G6PD (glucose-6-phosphate dehydrogenase) is mapped to human chromosome Xq28 and spans 16.2 kb. One G6PD monomer is composed of 515 amino acids with a predicted molecular weight of 59,256 Da. The active enzyme exists as a dimer and contains an NADP molecule tightly bound to it.

Immunogen

Peptide with sequence C-STNSDDVRDEKVK from the internal region of the protein sequence according to NP_000393.4 ; NP_001035810.1.

Biochem/physiol Actions

G6PD (glucose-6-phosphate dehydrogenase) enzyme catalyzes the oxidation of glucose-6-phosphate to 6-phosphogluconolactone, reducing NADP to NADPH. It therefore, catalyzes the first step of hexose monophosphate pathway (HMP). As it oxidizes glucose-6-phosphate, it confers protection against oxidative damage in erythrocytes. Its deficiency is highly heterogeneous, with around 190 variants being reported. The deficiency of G6PD was discovered while studying hemolytic anemia. G6PD also results in hereditary nonspherocytic hemolytic anemia.

Features and Benefits

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Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319
• Precautionary Statements: P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable