S4568

SCH 58261

≥98% (HPLC), adenosine receptor antagonist, solid

• Synonym(s): 7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine
• Empirical Formula (Hill Notation): C₁₈H₁₅N₇O
• CAS Number: 160098-96-4
• Molecular Weight: 345.36
• UNSPSC Code: 12352200
• PubChem Substance ID: 329824547
• NACRES: NA.77
• MDL number: MFCD00933778
• Assay: ≥98% (HPLC)
• Form: solid

Properties

• Product Name: SCH 58261, ≥98% (HPLC), solid
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• color: off-white
• solubility: DMSO: soluble >10 mg/mL, H₂O: insoluble
• SMILES string: Nc1nc2n(CCc3ccccc3)ncc2c4nc(nn14)-c5ccco5
• InChI: 1S/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22)
• InChI key: UTLPKQYUXOEJIL-UHFFFAOYSA-N

Description

Application

SCH 58261 was used to block A2α adenosine receptor to study the signaling by prostatic acid phosphatase in neurons.⁴

Biochem/physiol Actions

A_2A adenosine receptor antagonist.

SCH 58261 reduces the levels of TNF-α, Fas-L, Bax expression and activation of JNK-MAPK pathway. It has neuroprotective effects as it reduces demyelination of the neurons.[1] SCH 58261 increases the concentration of secretion of dopamine and elicits locomotor sensitization, an attractive option in the possible treatment of Parkinson′s disease.[2]

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)