P9246

PB28 dihydrochloride

≥98% (HPLC), solid

• Synonym(s): 1-Cyclohexyl-4-(3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-n-propyl)piperazine dihydrochloride
• Linear Formula: C₂₄H₄₀Cl₂N₂O
• CAS Number: 172906-90-0
• Molecular Weight: 443.49
• NACRES: NA.77
• PubChem Substance ID: 329820345
• UNSPSC Code: 12352200
• MDL number: MFCD06798349
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• color: white
• solubility: H₂O: ~10 mg/mL at 60 °C
• SMILES string: Cl[H].Cl[H].COc1cccc2C(CCCN3CCN(CC3)C4CCCCC4)CCCc12
• InChI: 1S/C24H38N2O.2ClH/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21;;/h6,12,14,20-21H,2-5,7-11,13,15-19H2,1H3;2*1H
• InChI key: DSRBJOQIBXACIV-UHFFFAOYSA-N

Description

Application

PB28 dihydrochloride has been used to test its inhibitory effect on potassium voltage-gated channel, shab-related subfamily, member 1, Kv2.1.

Biochem/physiol Actions

PB28, a cyclohexylpiperazine derivative, is a sigma 1 (σ1)-R antagonist. It elicits anti-tumor activity in breast, ovarian and colorectal cancer cell lines.

Selective σ₂ opioid receptor ligand; putative σ₂ agonist

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves