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Phenyl isothiocyanate

Name: Phenyl isothiocyanate
Brand: SIGMA

Sigma Grade, 8.36 M, suitable for solid phase protein sequencing analysis, ≥99% (GC), liquid

Synonym(s):

PITC

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About This Item

Linear Formula:

C₆H₅NCS

CAS Number:

103-72-0

Molecular Weight:

135.19

UNSPSC Code:

12352118

NACRES:

NA.31

PubChem Substance ID:

24898144

EC Number:

203-138-1

Beilstein/REAXYS Number:

471392

MDL number:

MFCD00004798

Assay:

≥99% (GC)

Form:

liquid

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Properties

grade

Sigma Grade

Quality Segment

100

assay

≥99% (GC)

form

liquid

concentration

8.36 M

refractive index

n20/D 1.6515 (lit.)

bp

218 °C (lit.)

mp

−21 °C (lit.)

density

1.132 g/mL at 20 °C (lit.)

suitability

suitable for solid phase protein sequencing analysis

storage temp.

2-8°C

SMILES string

S=C=Nc1ccccc1

InChI

1S/C7H5NS/c9-6-8-7-4-2-1-3-5-7/h1-5H

InChI key

QKFJKGMPGYROCL-UHFFFAOYSA-N

Description

General description

Phenyl isothiocyanate belongs to the class of aromatic compounds with isothiocyanate groups. It is typically used as a precolumn derivatization agent for the formation of phenylthiocarbamyl amino acids for their subsequent determination using chromatography techniques.

Application

Phenyl isothiocyanate may be used in the polypeptide and protein sequencing at the subpicomole and subnanomole levels, respectively, by applying automated Edman chemistry followed by the analysis using high-performance liquid chromatography (HPLC) technique.

Derivatizing reagent for primary and secondary amines. Used in sequencing peptides by Edman degradation and in amino acid analyses by HPLC.

Packaging

One mL size packaged in flame sealed amber ampules under argon.
Ten mL size packaged in screw cap amber vials under argon.

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This Item	78780	317861	139742
Sigma-Aldrich P1034 Phenyl isothiocyanate	Sigma-Aldrich 78780 Phenyl isothiocyanate	Sigma-Aldrich 317861 Phenyl isothiocyanate	Sigma-Aldrich 139742 Phenyl isothiocyanate
description Sigma Grade, 8.36 M, suitable for solid phase protein sequencing analysis, ≥99% (GC), liquid	description for HPLC derivatization, the detection of alcohols and amines, ≥99.0%	description 99%, for protein sequencing	description reagent grade, 98%
assay ≥99% (GC)	assay ≥99.0%	assay 99%	assay 98%
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 200
density 1.132 g/mL at 20 °C (lit.)	density 1.132 g/mL at 20 °C (lit.), 1.13 g/mL at 20 °C	density 1.132 g/mL at 20 °C (lit.)	density 1.132 g/mL at 20 °C (lit.)
refractive index n20/D 1.6515 (lit.)	refractive index n20/D 1.649, n20/D 1.6515 (lit.)	refractive index n20/D 1.6515 (lit.)	refractive index n20/D 1.6515 (lit.)
form liquid	form liquid	form liquid	form liquid
bp 218 °C (lit.)	bp 218 °C (lit.)	bp 221 °C, 218 °C (lit.)	bp 218 °C (lit.)

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Pictograms

GHS06,GHS08,GHS05

Signal Word

Danger

Hazard Codes

H301,H314,H317,H334

Precautionary Statements

P261 - P272 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point (°F)

190.4 °F - closed cup

Flash Point (°C)

88 °C - closed cup

PPE (personal protective equipment)

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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