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P0500

Palmitic acid

≥99%

Palmitic acid

Synonym(s):

1-Pentadecanecarboxylic acid, C16:0, Cetylic acid, Hexadecanoic acid, NSC 5030, PamOH

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About This Item

Linear Formula:
CH3(CH2)14COOH
CAS Number:
Molecular Weight:
256.42
UNSPSC Code:
12352106
NACRES:
NA.25
PubChem Substance ID:
EC Number:
200-312-9
Beilstein/REAXYS Number:
607489
MDL number:
Assay:
≥99%
Concentration:
≥99%
Form:
powder
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vapor pressure

10 mmHg ( 210 °C)

Quality Level

assay

≥99%

form

powder

concentration

≥99%

bp

271.5 °C/100 mmHg (lit.)

mp

61-62.5 °C (lit.)

solubility

water: soluble 0,00005 g/L at 20 °C

density

0.852 g/mL at 25 °C (lit.)

functional group

carboxylic acid

lipid type

saturated FAs

shipped in

ambient

storage temp.

room temp

SMILES string

CCCCCCCCCCCCCCCC(O)=O

InChI

1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)

InChI key

IPCSVZSSVZVIGE-UHFFFAOYSA-N

Gene Information

General description

Palmitic acid (PA), a saturated fatty acid present in the human body, accounts for 20-30% of total fatty acids (FA) in membrane phospholipids (PL) and adipose triacylglycerols (TAG). It is one of the main components of palm oil however, significant amounts of PA are also found in meat and dairy products, cocoa butter, and olive oil. PA is also present in breast milk. PA performs various fundamental biological functions at cellular and tissue levels.

Application

Palmitic acid has been used:
  • to study its effects on monocyte chemoattractant protein-1 (MCP-1) expression in adipocytes and THP-1 macrophages
  • to stimulate lipotoxicity in primary rat hepatocytes
  • in Et-bovine serum albumin (BSA) solution along with retinoic acid (RA) and retinol to study its effects on spermatogenesis or meiotic progression


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This Item
W283207PHR11201492007
concentration

≥99%

concentration

-

concentration

-

concentration

-

assay

≥99%

assay

≥98%

assay

-

assay

-

Quality Level

200

Quality Level

300, 400

Quality Level

300

Quality Level

-

form

powder

form

solid

form

-

form

flakes

solubility

water: soluble 0,00005 g/L at 20 °C

solubility

water: 0.00005 g/L at 20 °C

solubility

-

solubility

water: 0.00005 g/L at 20 °C

storage temp.

room temp

storage temp.

-

storage temp.

2-8°C

storage temp.

-


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Storage Class

11 - Combustible Solids

wgk

nwg

flash_point_f

235.4 °F

flash_point_c

113 °C

ppe

dust mask type N95 (US), Eyeshields, Gloves



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Jorge Matias Caviglia et al.
Journal of lipid research, 52(9), 1636-1651 (2011-07-02)
Although short-term incubation of hepatocytes with oleic acid (OA) stimulates secretion of apolipoprotein B100 (apoB100), exposure to higher doses of OA for longer periods inhibits secretion in association with induction of endoplasmic reticulum (ER) stress. Palmitic acid (PA) induces ER
Songtao Li et al.
Biochimica et biophysica acta, 1841(1), 22-33 (2013-09-24)
Saturated fatty acids (SFAs) induce hepatocyte cell death, wherein oxidative stress is mechanistically involved. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a master transcriptional regulator of cellular antioxidant defense enzymes. Therefore, Nrf2 activation is regarded as an effective strategy against
Chen Shen et al.
Journal of cellular and molecular medicine, 22(7), 3572-3581 (2018-04-20)
Lipotoxicity induced by saturated fatty acids (SFAs) plays a pathological role in the development of non-alcoholic fatty liver disease (NAFLD); however, the exact mechanism(s) remain to be clearly elucidated. Toll-like receptor (TLR) 4 plays a fundamental role in activating the



Global Trade Item Number

SKUGTIN
P0500-10G04061835547234
P0500-100G04061835547227
P0500-25G04061835547241
P0500-250G04061832864921

Questions

1–6 of 6 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. How long does it last in solution and how long does it last in powder form?

    1 answer
    1. This product is not assigned an expiration date, however, batches are retested every three years while stock is available. The material is soluble in chloroform at 100 mg/mL, ethanol at 30 mg/mL, DMSO at 20 mg/mL, and Dimethyl Formamide at 20 mg/mL. While it is recommended to purge stock solutions with inert gas, the long term storage and stability have not been determined. Upon dilution with aqueous buffers or medium, working solutions should not be stored longer than one day.

      Helpful?

  4. Hola, este compuesto es estable a largo plazo? A qué temperatura debería almacenarse una vez solubilizado en DMSO/Etanol a 80mM ? Muchas gracias de antemano

    1 answer
    1. Unfortunately, the stability of this product in solution is not determined.

      Helpful?

  5. What is the solubility?

    1 answer
    1. This product is tested for solubility at 100 mg/mL in Chloroform. The item is also soluble in DMSO (purged with inert gas) at 20 mg/mL. Other sources report that this material is also soluble in Ethanol.

      Helpful?

  6. Hello , Do you provide Halal / Kosher / Vegan certificate for RSPO grade Palmitic acid

    1 answer
    1. This product is listed as an M-Clarity level 200. For this quality level product only limited documentation is available and Halal, Kosher, and Vegan certificate are not provided. See the link below to learn more about the various quality levels and what these levels entail:
      https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management/m-clarity-program

      Should this level of documentation be required, see the links below to the Food Grade product options available.

      W283207
      https://www.sigmaaldrich.com/US/en/product/aldrich/w283207

      W283215
      https://www.sigmaaldrich.com/US/en/product/aldrich/w283215

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