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Pifithrin-μ

Name: Pifithrin-μ
Brand: SIGMA

≥97% (HPLC), solid

Synonym(s):

2-Phenylethynesulfonamide, PFTμ

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About This Item

Empirical Formula (Hill Notation):

C₈H₇NO₂S

CAS Number:

64984-31-2

Molecular Weight:

181.21

NACRES:

NA.77

PubChem Substance ID:

24724568

UNSPSC Code:

12352200

MDL number:

MFCD00181531

Assay:

≥97% (HPLC)

Form:

solid

Storage condition:

desiccated

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Properties

Quality Segment

100

assay

≥97% (HPLC)

form

solid

storage condition

desiccated

solubility

DMSO: soluble >10 mg/mL, clear, H₂O: insoluble

storage temp.

2-8°C

SMILES string

NS(=O)(=O)C#Cc1ccccc1

InChI

1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11)

InChI key

ZZUZYEMRHCMVTB-UHFFFAOYSA-N

Description

Application

Pifithrin-μ has been used:

to treat microglial cell line to analyse its neuroprotective effect on M1-like and M2-like phenotype
as heat shock protein (HSP)-70 inhibitor, to treat transfected Marc-145 cells
to inhibit heat shock cognate 70 (Hsc70) to elucidate heat shock chaperones mouse embryonic stem cells

Biochem/physiol Actions

Pifithrin-μ is an inhibitor of p53 binding and anti-apoptotic, which directly inhibits p53 binding to mitochondria as well as to Bcl-xL and Bcl-2 proteins.

Pifithrin-μ is an inhibitor of p53 binding and anti-apoptotic, which directly inhibits p53 binding to mitochondria as well as to Bcl-xL and Bcl-2 proteins. PFTμ rescues cells from lethal γ-irradiation-induced cell death. Because pifithrin-μ shuts down only the p53-mitochondrial pathway without affecting the transcriptional functions of p53, it is superior to pifithrin-α.

Pifithrin-μ(PFT-μ) has neuroprotective capabilities against cell death in a preclinical model of hypoxia-ischemia (HI)-induced neonatal encephalopathy. It inhibits nuclear factor-ΙB (NF-ΙB) pathway by inhibiting the interaction of molecular chaperone heat shock protein (HSP)-70 with its substrates.

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1 of 1

This Item	506155	G5547	T2952
Sigma-Aldrich P0122 Pifithrin-μ	Sigma-Aldrich 506155 Pifithrin-μ	Sigma-Aldrich G5547 GSK837149A	Sigma-Aldrich T2952 Tetrabenazine
form solid	form solid	form solid	form solid
assay ≥97% (HPLC)	assay ≥95% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
storage condition desiccated	storage condition OK to freeze, protect from light	storage condition -	storage condition -
solubility DMSO: soluble >10 mg/mL, clear, H₂O: insoluble	solubility DMSO: 50 mg/mL	solubility DMSO: >10 mg/mL, H₂O: insoluble	solubility DMSO: >10 mg/mL, H₂O: insoluble

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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