M5441

Mibefradil dihydrochloride hydrate

≥98% (HPLC), powder, T-type Ca²⁺ channel blocker

• Synonym(s): (1S,2S)-2-[2[[3-(2-Benzimidazolyl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphthyl methoxyacetate dihydrochloride hydrate, Ro 40-5967 hydrate
• Empirical Formula (Hill Notation): C₂₉H₃₈FN₃O₃ · 2HCl · xH₂O
• CAS Number: 116666-63-8
• Molecular Weight: 568.55 (anhydrous basis)
• MDL number: MFCD11044451
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278558
• NACRES: NA.77

Properties

• product name: Mibefradil dihydrochloride hydrate, ≥98% (HPLC), powder
• Assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white
• solubility: H₂O: soluble >20 mg/mL; absolute ethanol: insoluble
• originator: Roche
• SMILES string: O.Cl.Cl.COCC(=O)O[C@]3(CCN(C)CCCc1nc2ccccc2[nH]1)CCc4cc(F)ccc4[C@@H]3C(C)C
• InChI: 1S/C29H38FN3O3.2ClH.H2O/c1-20(2)28-23-12-11-22(30)18-21(23)13-14-29(28,36-27(34)19-35-4)15-17-33(3)16-7-10-26-31-24-8-5-6-9-25(24)32-26;;;/h5-6,8-9,11-12,18,20,28H,7,10,13-17,19H2,1-4H3,(H,31,32);2*1H;1H2/t28-,29-;;;/m0.../s1
• InChI key: IZSWBBGKLWFDOC-YKXHUFBBSA-N

Description

Application

Mibefradil has been used as a T-type calcium channel blocker in various cells. It has also been used to reduce apoptosis of retinal ganglion cells (RGC) in EphB2-Fc.

Biochem/physiol Actions

Mibefradil is a tetralol derivative and nondihydropyridine calcium channel blocker. It blocks long-type (L-type) calcium channels. It blocks mildly the Purkinje-type (P-type) calcium channels in Purkinje neurons.

Ro 40-5967 is a T-type Ca²⁺ channel blocker; antihypertensive.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves