M5269

Moniliformin sodium salt

from Fusarium proliferatum, tricarboxylic acid (TCA) cycle oxidation inhibitor

• Synonym(s): 1-Hydroxycyclobut-1-ene-3,4-dione
• Linear Formula: C₄HO₃Na
• CAS Number: 71376-34-6
• Molecular Weight: 120.04
• UNSPSC Code: 12352200
• PubChem Substance ID: 24896991
• NACRES: NA.77
• MDL number: MFCD00056566

Properties

• Product Name: Moniliformin sodium salt from Fusarium proliferatum,
• Quality Segment: 200
• storage temp.: 2-8°C
• SMILES string: O=C1C(C=C1[O-])=O.[Na+]
• InChI: 1S/C4H2O3.Na/c5-2-1-3(6)4(2)7;/h1,5H;/q;+1/p-1
• InChI key: FERDNJVXTWPNSA-UHFFFAOYSA-M

Description

General description

Moniliformin (MON), a mycotoxin and small ionic molecule, is present in various Fusarium species including Fusarium avenaceum, Fusarium subglutinans and Fusarium proliferatum. It is present as sodium or potassium salt of semisquaric acid naturally. MON is also present in maize and small-grain cereals.

Application

Moniliformin sodium salt from Fusarium proliferatum has been used as a mycotoxin standard:

• to test its acute oral toxicity in mice
• to test its subacute toxic effects in rats
• in characterizing mycotoxins from Aspergillus

Biochem/physiol Actions

Moniliformin (MON) is implicated for its toxic potential and may lead to respiratory distress and progressive muscular weakness in rats. It inhibits the tricarboxylic acid (TCA) cycle oxidation step. By acting as a pyruvate substrate, MON effectively inhibits thiamine pyrophosphate cofactor dependant enzymes and blocks the gluconeogenesis pathway. ) Furthermore, MON also inhibits glutathione peroxidase and glutathione reductase leading to oxidative stress in myoblast.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Codes: H301
• Precautionary Statements: P301 + P310
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges