Hydroxyurea decomposes in the presence of moisture, making aqueous solutions likely unstable. Solutions should be prepared immediately before use. This product is not sterile.
H8627
Hydroxyurea
98% (elemental analysis), powder, RNR inhibitor
Synonym(s):
Hydroxycarbamide
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About This Item
Linear Formula:
NH2CONHOH
CAS Number:
Molecular Weight:
76.05
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
204-821-7
MDL number:
Beilstein/REAXYS Number:
1741548
Assay:
98%
Form:
powder
Pricing and availability is not currently available.
Product Name
Hydroxyurea, 98%, powder
Quality Segment
assay
98%
form
powder
color
white
solubility
H2O: 50 mg/mL
storage temp.
2-8°C
SMILES string
NC(=O)NO
InChI
1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
InChI key
VSNHCAURESNICA-UHFFFAOYSA-N
Gene Information
human ... CA1(759), CA2(760), CYP1A2(1544), RRM1(6240), RRM2(6241), RRM2B(50484)
General description
Hydroxyurea is a hydroxylated analog of urea. It is beneficial in increasing fetal hemoglobin (HbF) levels, which in turn reduces the frequency of severe crises and the need for blood transfusions in sickle cell anemia patients. Hydroxyurea exhibits cell-cycle specificity for the S phase, leading to cell arrest at G1 to S. This non-alkylating S phase-specific myelosuppressive agent has a mechanism of action that is not specific to platelets.
Application
Hydroxyurea has been used:
- for cell cycle synchronization in MCF-7 human breast carcinoma cells, Schizosaccharomyces pombe, primary root of seedling
- as a drug for treating the parasite Leishmania mexicana in cell viability and cell cycle assay
- as an inhibitor in the cell adhesion and motility assay in Caki control and CD9 knockdown cells
Biochem/physiol Actions
Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase.
Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
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This Item | |||
|---|---|---|---|
| form powder | form solid | form solid | form - |
| assay 98% | assay - | assay ≥98% (HPLC) | assay - |
| Quality Level 200 | Quality Level 300 | Quality Level 100 | Quality Level - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility H2O: 50 mg/mL | solubility - | solubility water: 5 mg/mL | solubility - |
| color white | color - | color white | color - |
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signalword
Danger
hcodes
pcodes
Hazard Classifications
Muta. 1B - Repr. 2
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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How long is Hydroxyurea stable for once resuspended in water? Still store at 2-8C once resuspended? Is it sterile (suitable for cell culture work)?
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