![[D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt ≥97% (HPLC)](/deepweb/assets/sigmaaldrich/product/structures/227/014/768064c2-9ae6-47bd-8550-e2aa5c3b61de/640/768064c2-9ae6-47bd-8550-e2aa5c3b61de.png)
![[Met5]Enkephalin acetate salt hydrate ≥95.0% (HPLC), powder](/deepweb/assets/sigmaaldrich/product/structures/158/699/80b4b65b-7e48-49a2-ba61-4433cf1f375c/640/80b4b65b-7e48-49a2-ba61-4433cf1f375c.png)
![[D-Ala2]-Deltorphin II ≥97% (HPLC)](/deepweb/assets/sigmaaldrich/product/structures/289/271/db4c3fc4-8ba9-46ef-b214-158c9758871f/640/db4c3fc4-8ba9-46ef-b214-158c9758871f.png)
This compound can be dissolved in DMSO, where it should be soluble to a concentration of 30 mg/mL.
E7384
[D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt
≥97% (HPLC), μ-opioid receptors agonist
Synonym(s):
DAGO, DAMGO, Tyr-D-Ala-Gly-N-methyl-Phe-Gly-ol
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
| Pack Size | SKU | Availability | Price |
|---|
About This Item
Empirical Formula (Hill Notation):
C26H35N5O6
CAS Number:
Molecular Weight:
513.59
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.32
MDL number:
Pricing and availability is not currently available.
Product Name
[D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt, ≥97% (HPLC)
Quality Level
assay
≥97% (HPLC)
storage temp.
−20°C
SMILES string
CC(O)=O.C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N(C)[C@@H](Cc2ccccc2)C(=O)NCCO
InChI
1S/C26H35N5O6.C2H4O2/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18;1-2(3)4/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36);1H3,(H,3,4)/t17-,21+,22+;/m1./s1
InChI key
XZZYKCKUDLGXJA-NJUGUJQKSA-N
Gene Information
human ... OPRM1(4988)
mouse ... OPRM1(18390)
rat ... OPRM1(25601)
General description
[D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt or DAMGO is a full agonist of the μ-opioid receptor.[1] μ-opioid receptor is encoded by the OPRM1 gene, which has a predominant expression in reward-processing areas of brain. It acts as a receptor for endogenous opioids such as β-endorphin, encephalin, as well as foreign opioids such as morphine, heroin, and methadone.[2]
Application
[D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt or DAMGO has been used:
- for use as a positive control in the assay of G-protein activation with μ-opioid receptor, to assay the inhibition of cAMP inhibition by DAMGO [1]
- for the determination of the suppression of contraction by opioid receptors [3]
- to determine whether the peripheral application of DAMGO suppresses the hypertonic saline (HS)-induced masseter nociception in slightly anaesthetized rats [4]
Biochem/physiol Actions
Enkephalin analog that is a selective agonist at μ-opioid receptors.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
1 of 1
This Item | |||
|---|---|---|---|
| assay ≥97% (HPLC) | assay ≥95.0% (HPLC) | assay ≥97% (HPLC) | assay ≥95% (HPLC) |
| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| Gene Information human ... OPRM1(4988) | Gene Information human ... OPRD1(4985), OPRM1(4988) | Gene Information human ... OPRD1(4985), OPRK1(4986), OPRM1(4988) | Gene Information human ... OPRD1(4985), OPRM1(4988) |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
B Driessen et al.
British journal of pharmacology, 108(2), 443-447 (1993-02-01)
1. Effects of opioid agonists on the purinergic and adrenergic components of neurogenic contractions and in some experiments on transmitter overflow were studied in the mouse isolated vas deferens. 2. When the vas deferens was stimulated every 2 min by
Jami L Saloman et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(42), 10769-10781 (2016-11-01)
Designer receptors exclusively activated by designer drugs (DREADDs) are an advanced experimental tool that could potentially provide a novel approach to pain management. In particular, expression of an inhibitory (Gi-coupled) DREADD in nociceptors might enable ligand-dependent analgesia. To test this
Mariana Spetea et al.
British journal of pharmacology, 174(15), 2444-2456 (2017-05-12)
The κ receptor has a central role in modulating neurotransmission in central and peripheral neuronal circuits that subserve pain and other behavioural responses. Although κ receptor agonists do not produce euphoria or lead to respiratory suppression, they induce dysphoria and
Global Trade Item Number
| SKU | GTIN |
|---|---|
| E7384-1MG | 04061826152713 |
| E7384-5MG | 04061832676784 |
| E7384-10MG | 04061833605042 |
| E7384-50MG | 04061832676777 |
-
DAMGO Acetate salt를 H2O에 녹이라고 되어있는데, 이를 DMSO에 녹여서 사용해도 괜찮을까요? Specification sheets says to dissolve DAMGO Acetate salt in H2O, is it okay to dissolve it in DMSO?
1 answer-
Helpful?
-