D7321

Diosmetin

• Synonym(s): 3′,5,7-Trihydroxy-4′-methoxyflavone, 4′-Methylluteolin, 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one, Luteolin 4′-methyl ether
• Empirical Formula (Hill Notation): C₁₆H₁₂O₆
• CAS Number: 520-34-3
• Molecular Weight: 300.26
• UNSPSC Code: 12352205
• NACRES: NA.25
• PubChem Substance ID: 329798848
• EC Number: 208-291-8
• Beilstein/REAXYS Number: 294492
• MDL number: MFCD00017425

Properties

• assay: ≥98% (HPLC)
• Quality Segment: 200
• form: powder
• color: light yellow to yellow
• solubility: DMSO: 1 mg/mL, clear, faintly yellow to greenish-yellow
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: 2-8°C
• SMILES string: COc1ccc(cc1O)C2=CC(=O)c3c(O)cc(O)cc3O2
• InChI: 1S/C16H12O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-7,17-19H,1H3
• InChI key: MBNGWHIJMBWFHU-UHFFFAOYSA-N

Description

General description

Diosmetin is a methylated aglycone flavone of diosmin.[1] It is present abundantly in citrus fruits, Olea europaea L. (olive tree) leaves[2], and in the legume of Acacia farnesiana tree.[1]

Application

Diosmetin has been used to test its protective effects on chronic stress memory and cognitive impairment in mice model.[2]

Biochem/physiol Actions

Diosmetin exhibits anti-inflammatory, anti-cancer, antimicrobial, phytoestrogenic, and neuroprotective properties.[2] It displays cytoprotective effects against lipopolysaccharide (LPS)-induced acute lung injury (ALI) by inhibiting nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome and activating nuclear factor erythroid 2–related factor 2 (Nrf2).[3]

Flavonoid from Citrus limon. Antioxidant. Inhibits carcinogen activation by inhibiting the CYP1A1 enzyme.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable