Skip to Content
Merck
All Photos(2)

Documents

C2211

Sigma-Aldrich

Z-Leu-Leu-Leu-al

≥90% (HPLC)

Synonym(s):

MG-132

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

Empirical Formula (Hill Notation):
C26H41N3O5
CAS Number:
133407-82-6
Molecular Weight:
475.62
MDL number:
MFCD00674886
UNSPSC Code:
12352209
PubChem Substance ID:
24892475
NACRES:
NA.32

product name

Z-Leu-Leu-Leu-al, ≥90% (HPLC)

Quality Level

200

Assay

≥90% (HPLC)

form

powder

color

white

solubility

DMSO: soluble

storage temp.

−20°C

SMILES string

[H]C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1

InChI

1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1

InChI key

TZYWCYJVHRLUCT-VABKMULXSA-N

Gene Information

human ... CTSB(1508) , NFKB1(4790) , PSMA1(5682)

Looking for similar products? Visit Product Comparison Guide

Amino Acid Sequence

Z-Leu-Leu-Leu-al

Application

Z-Leu-Leu-Leu-al or MG132 has been used as a proteasome inhibitor. It has also been used to test the ubiquitylation and sumoylation pathways in urchin embryos.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client*
Johannes W. Bigenzahn
Molecular and Cellular Proteomics (2016)
MG132, a proteasome inhibitor, induced death of calf pulmonary artery endothelial cells via caspase-dependent apoptosis and GSH depletion.
Anticancer Research (2010)
Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-? levels in brain
Benjamin W
Journal of Neurochemistry (2016)
Proteasome inhibitors: from research tools to drug candidates
Alexei F.Kisselev
Chemistry and Biology, 8(8), 739-758 (2001)
Vaino K. Hopsu-Havu, Mikko Jarvinen, Heidrun Kirschke
Proteolysis in Cell Functions (1997)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service