43794

1,4-Dithioerythritol

BioUltra, ≥99.0% (RT)

• Synonym(s): erythro-1,4-Dimercapto-2,3-butanediol, erythro-2,3-Dihydroxy-1,4-butanedithiol, Cleland’s reagent, DTE
• Linear Formula: HSCH₂CH(OH)CH(OH)CH₂SH
• CAS Number: 6892-68-8
• Molecular Weight: 154.25
• UNSPSC Code: 12161504
• NACRES: NA.25
• PubChem Substance ID: 57650194
• EC Number: 229-998-8
• Beilstein/REAXYS Number: 1719756
• MDL number: MFCD00063750

Properties

• product line: BioUltra
• Quality Segment: 200
• assay: ≥99.0% (RT)
• form: powder
• reaction suitability: reagent type: reductant
• impurities: insoluble matter, passes filter test, ≤0.5% 4,5-dihydroxy-1,2-dithiane
• pH: 4.0-6.0 (25 °C, 0.1 M in H₂O)
• mp: 82-84 °C (lit.), 82-85 °C
• solubility: H₂O: 0.1 M at 20 °C, clear, colorless
• anion traces: sulfate (SO₄^2-): ≤50 mg/kg
• cation traces: Al: ≤5 mg/kg, As: ≤0.5 mg/kg, Ba: ≤5 mg/kg, Bi: ≤5 mg/kg, Ca: ≤50 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤50 mg/kg, Li: ≤5 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Mo: ≤5 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Sr: ≤5 mg/kg, Zn: ≤5 mg/kg
• λ: 0.1 M in H₂O
• UV absorption: λ: 260 nm A_max: 0.400, λ: 280 nm A_max: 0.050
• storage temp.: 2-8°C
• SMILES string: O[C@@H](CS)[C@H](O)CS
• InChI: 1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4+
• InChI key: VHJLVAABSRFDPM-ZXZARUISSA-N

Description

Application

Reagent for maintaining −SH groups in the reduced state; quantitatively reduces disulfides.

Other Notes

Cleavage of disulfide bonds in proteins; Prevents oxidation of sulfhydryl-containing proteins during SDS-polyacrylamide gel electrophoresis.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H412
• pcodes: P264 - P270 - P273 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 3
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves