77460

2-Chloroacetophenone

purum, ≥98.0% (GC)

• Synonym(s): ω-Chloroacetophenone, Phenacyl chloride
• Linear Formula: C₆H₅COCH₂Cl
• CAS Number: 532-27-4
• Molecular Weight: 154.59
• UNSPSC Code: 12352100
• NACRES: NA.22
• PubChem Substance ID: 329767699
• EC Number: 208-531-1
• Beilstein/REAXYS Number: 507950
• MDL number: MFCD00000933
• Assay: ≥98.0% (GC)
• Form: crystals

Properties

• grade: purum
• Quality Segment: 200
• assay: ≥98.0% (GC)
• form: crystals
• bp: 244-245 °C (lit.)
• mp: 53-56 °C, 54-56 °C (lit.)
• density: 1.324 g/mL at 25 °C (lit.)
• functional group: chloro, ketone, phenyl
• SMILES string: ClCC(=O)c1ccccc1
• InChI: 1S/C8H7ClO/c9-6-8(10)7-4-2-1-3-5-7/h1-5H,6H2
• InChI key: IMACFCSSMIZSPP-UHFFFAOYSA-N
• Gene Information: human ... PTPN6(5777)

Description

General description

2-Chloroacetophenone is an organic building block used in the synthesis of heterocyclic compounds. It has low solubility in water but can be soluble in alcohols, ethers and other organic solvents.

Application

2-Chloroacetophenone can be used in the synthesis of phenyl acetic acid by Photo-Favorskii rearrangement. It is also used in the preparation of 1-(2-chlorophenyl)ethanol via asymmetric hydrogenation reaction.

Safety Information

• Pictograms: GHS06,GHS08,GHS05
• Signal Word: Danger
• Hazard Codes: H300,H311 + H331,H315,H318,H334,H335
• Precautionary Statements: P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Eye Dam. 1 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges