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Merck

61347

10,11-Dihydro-10-hydroxycarbamazepine

analytical standard

Synonym(s):

10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide, Licarbazepine

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About This Item

Empirical Formula (Hill Notation):
C15H14N2O2
CAS Number:
Molecular Weight:
254.28
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
Beilstein/REAXYS Number:
1540211
MDL number:
Technical Service
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grade

analytical standard

Quality Level

assay

≥99% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

N1(c2c(cccc2)C(Cc3c1cccc3)O)C(=O)N

InChI

1S/C15H14N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8,14,18H,9H2,(H2,16,19)

InChI key

BMPDWHIDQYTSHX-UHFFFAOYSA-N

General description

10,11-Dihydro-10-hydroxycarbamazepine is an active metabolite of the antiepileptic drug, oxcarbazepine.
10,11-Dihydro-10-hydroxycarbamazepine is a 10-hydroxy derivative and an active metabolite of oxcarbazepine.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
10,11-Dihydro-10-hydroxycarbamazepine may be used as a reference standard in the determination of 10,11-dihydro-10-hydroxycarbamazepine in biological samples using liquid chromatography, liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) and high performance liquid chromatography coupled with ultraviolet detector (HPLC-UV).


pictograms

Environment

hcodes

pcodes

Hazard Classifications

Aquatic Chronic 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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First dose and steady-state pharmacokinetics of oxcarbazepine and its 10-hydroxy metabolite.
Dickinson R G, et al.
European Journal of Clinical Pharmacology, 37(1), 69-74 (1989)
Simultaneous high-performance liquid chromatography determination of carbamazepine and five of its metabolites in plasma of epileptic patients.
Mandrioli R, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 762(2), 109-116 (2001)
Juhyun Sim et al.
Forensic science international, 274, 91-98 (2017-01-24)
In recent years, the inappropriate use of antipsychotics by young Korean men has become a social problem. As military service exemptions are given for mental illness, some men pose as mental health patients to avoid military service. In order to



Global Trade Item Number

SKUGTIN
61347-25MG04061832700007