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α-Ketoglutaric acid

analytical standard

Synonym(s):

2-Oxoglutaric acid, 2-Oxopentanedioic acid

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About This Item

Linear Formula:
HOOCCH2CH2COCOOH
CAS Number:
Molecular Weight:
146.10
Beilstein:
1705689
EC Number:
MDL number:
UNSPSC Code:
41116107
NACRES:
NA.24

grade

analytical standard

Assay

99.0-101.0% (T)

shelf life

limited shelf life, expiry date on the label

application(s)

clinical testing

format

neat

storage temp.

2-8°C

SMILES string

OC(=O)CCC(=O)C(O)=O

InChI

1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)

InChI key

KPGXRSRHYNQIFN-UHFFFAOYSA-N

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General description

α-Ketoglutaric acid, an α-ketoacid, is identified as a potential, renal cell carcinoma (RCC) biomarker via urinary metabolomic profiling. It plays an important role in living beings as an angiogenesis suppressor.

Application

α-Ketoglutaric acid may be used as an analytical reference standard for the quantification of the analyte in the following:
  • Human plasma samples using gas-chromatography coupled to mass spectrometry.
  • Beer samples using high-performance liquid chromatography with UV detection, and further confirmed by high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS).
  • Fruits and vegetables using HPLC-MS/MS.

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Eye Dam. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Simultaneous determination of urinary quinolinate, gentisate, 4-hydroxybenzoate, and ?-ketoglutarate by high-performance liquid chromatography-tandem mass spectrometry
Chen S, et al.
Analytical Methods : Advancing Methods and Applications, 7(16), 6572-6578 (2015)
Simultaneous quantitative determination of ?-ketoglutaric acid and 5-hydroxymethylfurfural in human plasma by gas chromatography?mass spectrometry
Wagner MB, et al.
Analytical and Bioanalytical Chemistry, 396(7), 2629-2637 (2010)
Single determination of ?-ketoglutaric acid and pyruvic acid in beer by HPLC with UV detection
Montenegro P, et al.
Analytical Methods : Advancing Methods and Applications, 3(5), 1207-1212 (2011)
Gas chromatographic profiling and pattern recognition analysis of urinary organic acids from uterine myoma patients and cervical cancer patients
Kim R-K, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 712(1-2), 11-22 (1998)
Determination of organic acids in fruits and vegetables by liquid chromatography with tandem-mass spectrometry
Flores P, et al.
Food Chemistry, 132(2), 1049-1054 (2012)

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