8.40130

4-Hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl

(free radical) for synthesis

• Synonym(s): 4-Hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-Hydroxy-TEMPO
• Empirical Formula (Hill Notation): C₉H₁₈NO₂
• CAS Number: 2226-96-2
• Molecular Weight: 172.24
• UNSPSC Code: 12352119
• EC Index Number: 218-760-9
• NACRES: NA.22
• MDL number: MFCD00006478
• Assay: ≥95.0% (GC)
• Form: crystals

Properties

• vapor pressure: <0.01 hPa ( 20 °C)
• Quality Segment: 200
• assay: ≥95.0% (GC)
• form: crystals
• autoignition temp.: 260 °C (DIN 51794)
• potency: 1053 mg/kg LD₅₀, oral (Rat)
• pH: 8.2 (20 °C, 20 g/L in H₂O)
• mp: 67-71 °C
• transition temp: flash point 146 °C (DIN 51758)
• solubility: 1670 g/L
• storage temp.: 2-30°C
• SMILES string: [N+]1(C(CC(CC1(C)C)O)(C)C)[O-]
• InChI: 1S/C9H18NO2/c1-8(2)5-7(11)6-9(3,4)10(8)12/h7,11H,5-6H2,1-4H3
• InChI key: UZFMOKQJFYMBGY-UHFFFAOYSA-N

Description

Application

• Vitamin C Determination: A study that utilizes TEMPO for a simple and rapid determination of vitamin C content in various fruits, showcasing an economical approach to antioxidant testing (Ihara et al., 2017).


• Herbicide Development: A study on the synthesis of phenoxy carboxylic herbicides based on the piperidine scaffold, where TEMPO derivatives showed unexpected fungicidal activity (Zakrzewski & Krawczyk, 2014).

Analysis Note

Assay (GC, area%): ≥ 95.0 % (a/a)
Melting range (lower value): ≥ 67 °C
Melting range (upper value): ≤ 71 °C
Identity (IR): passes test

Safety Information

• Signal Word: Danger
• Precautionary Statements: P260 - P264 - P280 - P301 + P312 - P305 + P351 + P338 - P314
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - STOT RE 2 Oral
• Storage Class: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): 294.8 °F - DIN 51758
• Flash Point (°C): 146 °C - DIN 51758
• Target Organs: Liver,spleen
• Pictograms: GHS08,GHS05,GHS07
• Hazard Codes: H302,H318,H373