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05-23-0050

Sigma-Aldrich

Corticotropin Releasing Factor, Human and Rat

An immunomodulatory neuropeptide that acts to release ACTH from the anterior pituitary and stimulates the sympathetic nervous system and adrenal medulla.

Synonym(s):

Corticotropin Releasing Factor, Human and Rat, CRF, CRH, Corticotropin-releasing hormone

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About This Item

Empirical Formula (Hill Notation):
C208H344N60O63S2
CAS Number:
Molecular Weight:
4757.45
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.32

Quality Level

Assay

≥97% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

technique(s)

cell based assay: suitable

color

white to off-white

solubility

5% NH4OH: 1 mg/mL (prepared with H₂O)

UniProt accession no.

shipped in

ambient

storage temp.

−20°C

InChI key

VXFVFWFSJFSXHN-FAUHKOHMSA-N

Gene Information

human ... CRH(1392)

General description

Research area: Neuroscience

Corticotropin-releasing factor (CRF), a 41-amino-acid peptide, is widely expressed in neurons throughout the mammalian brain and several peripheral tissues such as the pancreas, stomach, and small intestine. It functions by stimulating the secretion of corticotropin in the anterior pituitary, which in turn regulates adrenal cortex synthetic/secretory activity. Human CRF is located on chromosome 8q13 and is identical to rat and mouse CRF. It assumes a random coil structure under physiological conditions and α-helix shape in an amphiphilic environment.

Application

Corticotropin-releasing factor (CRF) has been used to investigate its effects on Cerebellar Motor Control and Ataxia in rats.

Biochem/physiol Actions

Cell permeable: no

Primary Target: An immunomodulatory neuropeptide

The product does not compete with ATP.

Reversible: no

Corticotropin-releasing factor (CRF), a neuropeptide also known as corticotropin-releasing factor (CRH), plays a crucial role in the stress response by activating the hypothalamic-pituitary-adrenal (HPA) axis and extrahypothalamic pathways. It acts by releasing Adrenocorticotropic Hormone (ACTH) from the anterior pituitary, stimulating the sympathetic nervous system and adrenal medulla. Besides its involvement in stress regulation, CRF peptides have diverse effects on both, the central nervous system and peripheral tissues. This includes potential regulation of anxiety, mood, feeding, inflammation, gastric emptying, and blood pressure. Aberrant secretion of CRF could potentially contribute to the development of various neuropsychiatric disorders such as anxiety, depression, obsessive-compulsive disorder, Parkinson′s disease, Alzheimer′s disease, alcohol withdrawal, and post traumatic stress disorder. Also, CRF and CRF-R1 (Corticotropin-Releasing Factor Receptor 1) have been observed in lymphoid organs and sites of inflammation, suggesting a role in immune system regulation.

Packaging

Yes

Warning

Toxicity: Standard Handling (A)

Sequence

H-Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH₂

Physical form

Supplied as an acetate salt.

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Barmack, N.H., and Errico, P. 1993. J. Neurosci. 13, 4647.
Wei, E.T., et al. 1993. Ciba Found. Symp. 172, 258.
Smith, E.M., et al. 1986. Nature321, 881.
Udelsman, R., et al. 1986. Nature319, 147.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Physiology and pharmacology of corticotropin-releasing factor
Owens Michael J and Nemeroff Charles B
Pharmacological Reviews, 43(4) (1991)
Role of Corticotropin-Releasing Factor in Cerebellar Motor Control and Ataxia
Wang Y, et al.
Current Biology, 27(17), 2661-2669 (2017)
Immunomodulatory role of the corticotropin-releasing factor
M Radulovic and J Spiess
Archivum Immunologiae et Therapiae Experimentalis, 49(1), 33-38 (2001)
CRH
D. Richard and C. Lopez
Handbook of Biologically Active Peptides, 1084-1088 (2013)
Corticotropin releasing factor (CRF) receptor modulators: progress and opportunities for new therapeutic agents
Gilligan PJ, et al.
Journal of Medicinal Chemistry, 43(9), 1641-1660 (2000)

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