Skip to Content
Merck
  • The acetazolamide challenge: techniques and applications in the evaluation of chronic cerebral ischemia.

The acetazolamide challenge: techniques and applications in the evaluation of chronic cerebral ischemia.

AJNR. American journal of neuroradiology (2009-02-28)
A S Vagal, J L Leach, M Fernandez-Ulloa, M Zuccarello
ABSTRACT

The acetazolamide (ACZ) challenge test is a useful clinical tool and a reliable predictor of critically reduced perfusion. In patients with chronic steno-occlusive disease, the ability to maintain normal cerebral blood flow by reducing vascular resistance secondary to autoregulatory vasodilation is compromised. Identification of the presence and degree of autoregulatory vasodilation (reflecting the cerebrovascular reserve) is a significant prognostic factor in patients with chronic cerebrovascular disease. The pharmacologic challenge of a vasodilatory stimulus such as ACZ can also be used to optimize the treatment strategies for these patients. The pathophysiology, methods, and clinical applications of the ACZ challenge test are discussed in this article.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Acetazolamide, ≥99%, powder
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPrice
100 mL
Estimated to ship on 14 February 2025
$19.70
500 mL
Estimated to ship on 14 February 2025
$52.90
1 L
Estimated to ship on 20 February 2025
$107.00
6 x 1 L
Estimated to ship on 14 February 2025
$248.00
6 x 500 mL
Estimated to ship on 14 February 2025
$282.00
24 x 500 mL
Estimated to ship on 17 March 2025
$498.00

To order products, please contact your local dealer.

Acetazolamide, European Pharmacopoeia (EP) Reference Standard
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPrice
100 mL
Estimated to ship on 14 February 2025
$19.70
500 mL
Estimated to ship on 14 February 2025
$52.90
1 L
Estimated to ship on 20 February 2025
$107.00
6 x 1 L
Estimated to ship on 14 February 2025
$248.00
6 x 500 mL
Estimated to ship on 14 February 2025
$282.00
24 x 500 mL
Estimated to ship on 17 March 2025
$498.00

To order products, please contact your local dealer.

Acetazolamide for system suitability, European Pharmacopoeia (EP) Reference Standard
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPrice
100 mL
Estimated to ship on 14 February 2025
$19.70
500 mL
Estimated to ship on 14 February 2025
$52.90
1 L
Estimated to ship on 20 February 2025
$107.00
6 x 1 L
Estimated to ship on 14 February 2025
$248.00
6 x 500 mL
Estimated to ship on 14 February 2025
$282.00
24 x 500 mL
Estimated to ship on 17 March 2025
$498.00

To order products, please contact your local dealer.

USP
Acetazolamide, United States Pharmacopeia (USP) Reference Standard
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPrice
100 mL
Estimated to ship on 14 February 2025
$19.70
500 mL
Estimated to ship on 14 February 2025
$52.90
1 L
Estimated to ship on 20 February 2025
$107.00
6 x 1 L
Estimated to ship on 14 February 2025
$248.00
6 x 500 mL
Estimated to ship on 14 February 2025
$282.00
24 x 500 mL
Estimated to ship on 17 March 2025
$498.00

To order products, please contact your local dealer.