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SML3612

Sigma-Aldrich

Ganoderic acid D

≥95% (HPLC)

Synonym(s):

(7β)-7-Hydroxy-3,11,15,23-tetraoxolanost-8-en-26-oic acid, GAD

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About This Item

Empirical Formula (Hill Notation):
C30H42O7
CAS Number:
Molecular Weight:
514.65
MDL number:
UNSPSC Code:
12352106
UNSPSC Code:
12352200
NACRES:
NA.21

Pricing and availability is not currently available.

Quality Level

Assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

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This Item
SMB00445U5127PHL89668
assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥99%

assay

≥90.0% (HPLC)

Quality Level

100

Quality Level

200

Quality Level

-

Quality Level

-

storage temp.

-10 to -25°C

storage temp.

−20°C

storage temp.

-

storage temp.

-

solubility

DMSO: 2 mg/mL, clear

solubility

-

solubility

-

solubility

-

color

white to beige

color

-

color

-

color

-

Biochem/physiol Actions

Ganoderic acid D is one of major triterpenes isolated from Ganoderma lucidum that exhibit potent anticancer properties. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate, and pyruvate and acetyl-coenzyme production through SIRT3 upregulation via acetylated cyclophilin D inhibition.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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    Ruo-Lin Zhao et al.
    Journal of ethnopharmacology, 210, 287-295 (2017-09-09)
    Ganoderma lucidum (GL) is an oriental medical fungus, which was used to prevent and treat many diseases. Previously, the effective compounds of Ganoderma lucidum extract (GLE) were extracted from two kinds of GL, [Ganoderma lucidum (Leyss. Ex Fr.) Karst.] and
    Zhendong Liu et al.
    European journal of pharmacology, 824, 72-77 (2018-01-29)
    Ganoderic acid D (GAD) is a highly oxygenated tetracyclic triterpenoid. This study aims to assess the effects of GAD on the energy metabolism of colon cancer through the regulation of SIRT3 expression and whether this effect is related to acetylated
    Qing-Xi Yue et al.
    Molecular & cellular proteomics : MCP, 7(5), 949-961 (2008-01-02)
    Triterpenes isolated from Ganoderma lucidum could inhibit the growth of numerous cancer cell lines and were thought to be the basis of the anticancer effects of G. lucidum. Ganoderic acid D (GAD) is one of the major components in Ganoderma

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