SML2008

Tiotropium bromide monohydrate

≥98% (HPLC)

• Synonym(s): (1α, 2β, 4 β, 5α, 7β)-7-[(Hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide monohydrate, 3-Oxa-9-azoniatricyclo[3.3.1.02,4]?nonane, 7-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-, bromide, hydrate (1:1:1), (1α,2β,4β,5α,7β), 6β,7β-epoxy-3β-hydroxy-8-methyl-1αH,5αH-tropanium bromide monohydrate, di-2-thienylglycolate
• Empirical Formula (Hill Notation): C₁₉H₂₂BrNO₄S₂ · H₂O
• CAS Number: 411207-31-3
• Molecular Weight: 490.43
• MDL number: MFCD23704176
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: H₂O: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: [H]O[H].O=C(C(C1=C([H])C([H])=C([H])S1)(O[H])C2=C([H])C([H])=C([H])S2)O[C@@]3([H])C([H])([H])[C@@]4([H])[C@@]5([H])[C@@](O5)([H])[C@](C3([H])[H])([H])[N+]4(C([H])([H])[H])C([H])([H])[H].[Br-]
• InChI: 1S/C19H22NO4S2.BrH.H2O/c1-20(2)12-9-11(10-13(20)17-16(12)24-17)23-18(21)19(22,14-5-3-7-25-14)15-6-4-8-26-15;;/h3-8,11-13,16-17,22H,9-10H2,1-2H3;1H;1H2/q+1;;/p-1/t11?,12-,13+,16?,17?;;
• InChI key: MQLXPRBEAHBZTK-YQMLGFMRSA-M

Description

Application

Tiotropium bromide monohydrate may be used as a long-acting muscarinic receptor antagonist (LAMA) in a comparative study to explore its efficacy in the downregulation of the cough reflex in rabbits.

Biochem/physiol Actions

Tiotropium Bromide is an anticholinergic bronchodilator. It is considered a long-acting muscarinic receptor antagonist (LAMA) and is used clinically as an inhaled bronchodilator for chronic obstructive pulmonary disease (COPD) and asthma.

Tiotropium bromide exhibits more beneficial effects on pulmonary function than other anticholinergic and β-2 adrenergic agents. Tiotropium can prevent the proliferation of fibroblasts and myofibroblasts induced by acetylcholine. It can block human monocyte chemotaxis.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable