S8689

Fas Ligand, soluble human

recombinant, expressed in HEK 293 cells, lyophilized powder

• Synonym(s): SuperFas Ligand^™
• UNSPSC Code: 12352202
• NACRES: NA.56
• MDL number: MFCD01092558
• Form: lyophilized powder
• Assay: ≥95% (SDS-GE)
• Biological source: human
• Recombinant: expressed in HEK 293 cells
• Mol wt: 32 kDa by SDS-PAGE (nonglycosylated form, under reducing conditions), 35 kDa by SDS-PAGE (glycosylated form, under reducing conditions)

Properties

• biological source: human
• Quality Segment: 200
• recombinant: expressed in HEK 293 cells
• assay: ≥95% (SDS-GE)
• form: lyophilized powder
• mol wt: 32 kDa by SDS-PAGE (nonglycosylated form, under reducing conditions), 35 kDa by SDS-PAGE (glycosylated form, under reducing conditions)
• technique(s): ligand binding assay: suitable
• UniProt accession no.: P48023
• storage temp.: −20°C
• Gene Information: human ... FASLG(356)

Description

Application

ED₅₀ = 1 ng/ml on A20 cells. Does not require any enhancer, as the modified linker sequence already facilitates the formation of active FasL complexes. rhsSuperFas Ligand^™ recognizes its receptor Fas (CD95) of the following species: human, rat, mouse.

Biochem/physiol Actions

Fas ligand has also been shown to be involved in the activation of non-apoptotic pathways including proliferation and NF-κ B activation. [1]

Fas ligand, a protein belonging to the tumor necrosis factor (TNF) family of cytokines, induces apoptosis in cells expressing the cell membrane receptor Fas (CD95/Apo-1).

Legal Information

SuperFas Ligand is a trademark of Alexis Biochemicals Corp.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable