S143

(±)-6-Chloro-PB hydrobromide

≥98% (HPLC), solid

• Synonym(s): (±)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide, (±)-SKF-81297 hydrobromide
• Empirical Formula (Hill Notation): C₁₆H₁₆ClNO₂ · HBr
• CAS Number: 71636-61-8
• Molecular Weight: 370.67
• MDL number: MFCD00153782
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277934
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• color: white to light tan
• solubility: H₂O: 1.7 mg/mL; DMSO: >10 mg/mL; ethanol: 6.3 mg/mL
• SMILES string: Br[H].Oc1cc2C(CNCCc2c(Cl)c1O)c3ccccc3
• InChI: 1S/C16H16ClNO2.BrH/c17-15-11-6-7-18-9-13(10-4-2-1-3-5-10)12(11)8-14(19)16(15)20;/h1-5,8,13,18-20H,6-7,9H2;1H
• InChI key: RMIJGBMRNYUZRG-UHFFFAOYSA-N
• Gene Information: human ... DRD1(1812)

Description

Application

(±)-6-Chloro-PB hydrobromide has been used as a dopamine D1 receptor (Drd1a) agonist to study the role of the drd1a-dopamine receptor inactivation of extracellular signal‑regulated protein kinase 1/2 (ERK1/2) in the wild-type and striatum of dopamine-depleted mice. It has also been used as a Drd1a agonist to identify the contribution of D1 (D1R)-like dopamine receptor signaling on learning and memory in Barnes maze in rats.

Biochem/physiol Actions

(+/-)-6-Chloro-PB HBr is a full D₁ dopamine receptor agonist.

Caution

Product is air and light sensitive

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves