SCT247
BioTracker MultiTASQ G-Quadruplex (G4) Cell Probe
Synonym(s):
G quadruplex probe, G4 ligand, G4 probe, G4 tetrad probe, Live Cell Imaging Probe, click chemistry probe
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About This Item
UNSPSC Code:
41106514
NACRES:
NA.52
Recommended Products
packaging
vial of 1 mg
Quality Level
manufacturer/tradename
Millipore
growth mode
N/A
technique(s)
DNA sequencing: suitable
RNA extraction: suitable
nucleic acid detection: suitable
detection method
fluorometric
shipped in
dry ice
storage temp.
−20°C
Application
DNA/RNA G-quadruplexes (G4s) are four-stranded nucleic acid structures that fold from numerous guanine (G)-rich sequences found in the genome and transcriptome. Their abundance and localization in critical regulatory regions make them key players in genetic diseases (cancer, neuropathology), but not only (e.g., viral infection). For this reason G4s have garnered intense interest as potential targets in different therapeutic areas
The BioTracker™ MultiTASQ G-quadruplex G4 cell probe is optimized for detection (1) and/or the isolation of G4s (2,3). MultiTASQ utilizes the template-assembled synthetic G-quartets (TASQ) (4) concept as a biomimetic ligand for G-quadruplexes, a design which results in high specificity for folded G4.
References
1. Nat. Chem. 2021, 13(7): 626-633
2. ACS Chem Biol. 2021, 16(5): 905-914
The BioTracker™ MultiTASQ G-quadruplex G4 cell probe is optimized for detection (1) and/or the isolation of G4s (2,3). MultiTASQ utilizes the template-assembled synthetic G-quartets (TASQ) (4) concept as a biomimetic ligand for G-quadruplexes, a design which results in high specificity for folded G4.
References
1. Nat. Chem. 2021, 13(7): 626-633
2. ACS Chem Biol. 2021, 16(5): 905-914
Purity: > 98% confirmed by HPLC, HNMR, LC-MS and elemental analysis.
Features and Benefits
MultiTASQ detects ribosomal RNA-G4 associated with perinuclear rough ER regions to a greater degree compared to BG4 antibody. MultiTASQ is an alkynylated probe that allows for background-free detection via click chemistry and is suitable for G4 capture chemi-precipitation and click imaging applications. MultiTASQ is compatible with live-cell incubation. The BioTracker MultiTASQ G4 cell probe is a uniquely designed, versatile tool for G4 detection and analysis.
Physical form
Lyophilized. White solid.
Storage and Stability
Store BioTracker BioCyTASQ G-quadruplex G4 cell probe at -20°C, desiccated and protected from light
Other Notes
Fluorescent detection of nucleic acid G4 quadruplexes in cells and tissues using click chemistry
Legal Information
BioTracker is a trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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