5.04596

TCN-201

• Synonym(s): TCN-201, 3-Chloro-4-fluoro-N-[(4-{[2-(phenylcarbonyl)hydrazino]carbonyl}phenyl)methyl]benzenesulfonamide, NMDA Antagonist X
• Empirical Formula (Hill Notation): C₂₁H₁₇ClFN₃O₄S
• CAS Number: 852918-02-6
• Molecular Weight: 461.89
• MDL number: MFCD06683895
• UNSPSC Code: 12352200

Properties

• Assay: ≥98% (HPLC)
• Quality Level: 100
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: 5 mg/mL
• storage temp.: 2-8°C
• InChI: 1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28)
• InChI key: FYIBXBFDXNPBSF-UHFFFAOYSA-N

Description

General description

A negative allosteric modulator selective for NR2A containing NMDA receptors (pIC₅₀ = 6.8 and <4.3 µM for NR2A and NR2B, respectively). No effect on NR2B-containing NMDA receptors with concentrations less than 50 mM. Inhibition on NR2A containing NMDA receptors is glycine (or D-serine)-binding, but not glutamate-binding, dependent.

Biochem/physiol Actions

Primary Target
NMDA receptors

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Bettini. E., et al. 2010. J. Pharm. Exp. Ther.335, 644.
Shin, A., et al. 2011. Br. J. Pharmacol.166, 1002.
Edman, S., et al. 2012. Neuropharmacology63, 441.
Hansen, K., et al. 2012. J. Neurosci.32, 6197.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315 - H319 - H335 - H336
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable