This product is a research grade Itopride and not considered a primary or secondary standard. Currently, there is no primary standard product available.
SML0033
Itopride hydrochloride
≥98% (HPLC)
Synonym(s):
N-[[4-[2-(Dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxy benzamidehydrochloride, N-[p-[2-(dimethylamino)ethoxy]benzyl]veratramide hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C20H26N2O4 ·HCl
CAS Number:
Molecular Weight:
394.89
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.
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Quality Level
Assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to tan
solubility
H2O: ≥48 mg/mL
originator
Abbott
storage temp.
2-8°C
SMILES string
Cl.COc1ccc(cc1OC)C(=O)NCc2ccc(OCCN(C)C)cc2
InChI
1S/C20H26N2O4.ClH/c1-22(2)11-12-26-17-8-5-15(6-9-17)14-21-20(23)16-7-10-18(24-3)19(13-16)25-4;/h5-10,13H,11-12,14H2,1-4H3,(H,21,23);1H
InChI key
ZTOUXLLIPWWHSR-UHFFFAOYSA-N
General description
Itopride hydrochloride is a new prokinetic drug.[1]
Biochem/physiol Actions
Antagonist of dopamine D2-receptor with anticholinesterase activity.
Itopride hydrochloride enhances the gastrointestinal motility by blocking the activity of dopamine on the D2 receptors, on the post-synaptic cholinergic nerves and by inducing the liberation of acetylcholine in the myenteric plexus. It also inhibits the hydrolysis of the released acetylcholine with the help of acetylcholinesterase.[1]
Itopride is an acetylcholinesterase (AChE) inhibitor and D2 dopamine receptor antagonist. Itopride is used as a gastroprokinetic agent.
Features and Benefits
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Customers Also Viewed
[Effect of HSR-803 on gastrointestinal motility].
H Iwanaga et al.
Nihon Heikatsukin Gakkai zasshi, 25(6), 313-315 (1989-12-01)
Sanjay Bansal et al.
Drug delivery, 23(2), 437-451 (2014-05-29)
The objectives of present studies were to develop the systematically optimized multiple-unit gastroretentive microballoons, i.e. hollow microspheres of itopride hydrochloride (ITH) employing quality by design (QbD)-based approach. Initially, the patient-centric QTPP and CQAs were earmarked, and preliminary studies were conducted
E Takahara et al.
Journal of chromatography, 576(1), 174-178 (1992-04-15)
A method based on high-performance liquid chromatography using column-switching is described for the simultaneous determination of HSR-803 and its metabolites in human serum and urine. The system uses a six-port valve with a Nucleosil CN pre-column for on-line sample clean-up
Comparative evaluation of the efficacy and tolerability of itopride hydrochloride and domperidone in patients with non-ulcer dyspepsia.
Sawant P, et al.
The Journal of the Association of Physicians of India, 52, 626-628 (2004)
Y Iwanaga et al.
Japanese journal of pharmacology, 56(3), 261-269 (1991-07-01)
To estimate the effect of a new gastroprokinetic agent, N-[4-[2-(dimethylamino)ethoxy]benzyl]-3,4-dimethoxybenzamide hydrochloride (HSR-803), on non-ulcer dyspepsia, the influence of HSR-803 on gastrointestinal propulsion was assayed in dogs, rats and mice in comparison with some gastroprokinetic agents. HSR-803 (30 mg/kg, p.o.) significantly
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Is the Itopride HCL CAS 122892-31-3 a primary standard grade or a reagent grade?
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