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Key Documents

PRS3905

Sigma-Aldrich

Anti-TRPC3 (ab3) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Short transient receptor potential channel 3, Anti-Transient receptor potential cation channel, subfamily C, member 3

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About This Item

MDL number:
MFCD02686005
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, human

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

Q13507

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TRPC3(7222)

General description

TRPC3 (transient receptor potential-canonical 3) belongs to TRPC family. It is present in sperm. It is located on chromosome 4q27.

Immunogen

a 14 amino acid peptide from near the carboxy-terminus of human TRPC3.

Application

Anti-TRPC3 has been used in immunofluorescent staining.

Biochem/physiol Actions

TRPC3 (transient receptor potential-canonical 3) participates in motility and capacitation of sperm. It is responsible for the proliferation of ovarian cancer cell in vitro and in vivo.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3905.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Description
Pricing

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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FSH enhances the proliferation of ovarian cancer cells by activating transient receptor potential channel C3
Tao X, et al.
Endocrine-Related Cancer, 20(3), 415-429 (2013)
Transient receptor potential-canonical 3 modulates sperm motility and capacitation-associated protein tyrosine phosphorylation via [Ca2+]i mobilization
Ru Y, et al.
Acta biochimica et biophysica Sinica, 47(6), 404-413 (2015)
TRP channels in endothelial function and dysfunction
Kwan HY, et al.
Biochimica et Biophysica Acta, 1772(8), 907-914 (2007)
Yanfei Ru et al.
Acta biochimica et biophysica Sinica, 47(6), 404-413 (2015-04-26)
Ca(2+) signaling is pivotal for sperm maturation, including the processes of motility, capacitation, and the acrosome reaction. As a Ca(2+) conductor, transient receptor potential-canonical 3 (TRPC3) plays an important role in somatic cells. However, the function of TRPC3 in sperm

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