H57807
4-Hydroxyquinazoline
98%
Synonym(s):
4-Quinazolinol
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About This Item
Empirical Formula (Hill Notation):
C8H6N2O
CAS Number:
Molecular Weight:
146.15
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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Assay
98%
mp
216-219 °C (lit.)
SMILES string
O=C1NC=Nc2ccccc12
InChI
1S/C8H6N2O/c11-8-6-3-1-2-4-7(6)9-5-10-8/h1-5H,(H,9,10,11)
InChI key
QMNUDYFKZYBWQX-UHFFFAOYSA-N
Gene Information
mouse ... Parp2(11546)
Related Categories
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Hao Wu et al.
Journal of combinatorial chemistry, 12(3), 346-355 (2010-03-04)
Three diversity points of 4(3H)-quinazolinone are introduced at the 3-, 6-, and 7-positions with an efficient parallel solution-phase synthetic method. A one-pot synthesis was developed that gave the key intermediate in high yield. Five hit compounds exhibit preferable activities against
Y Onishi et al.
Biochimica et biophysica acta, 1175(2), 147-154 (1993-01-17)
The effects of the inhibitors of topoisomerase I and II, camptothecin and etoposide, as well as novobiocin and adriamycin, on the DNA fragmentation and viability of mouse thymocytes in primary culture were examined. All inhibitors were shown to produce dose-dependent
V Krishnakumar et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 66(4-5), 1082-1090 (2006-07-28)
The solid phase FT-IR and FT-Raman spectra of 4-hydroxy quinazoline and 2-hydroxy benzimidazole have been recorded in the regions 4000-400 and 3500-100 cm-1, respectively. Theoretical information on the optimised geometry, harmonic vibrational frequencies, infrared and Raman intensities were obtained by
Majid M Heravi et al.
Ultrasonics sonochemistry, 16(6), 708-710 (2009-04-14)
A new synthesis of 4(3H)-quinazolinone from the reaction of 2-amino-benzamide, and acylchlorides in the presence of catalytic amounts of silica-supported Preyssler nano particles as green, reusable and efficient catalyst under ultra sonic irradiation is reported.
R Halmosi et al.
Molecular pharmacology, 59(6), 1497-1505 (2001-05-17)
Ischemia-reperfusion induces reactive oxygen species (ROS) formation, and ROS lead to cardiac dysfunction, in part, via the activation of the nuclear poly(ADP-ribose) polymerase (PARP, called also PARS and ADP-RT). ROS and peroxynitrite induce single-strand DNA break formation and PARP activation
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