567022
Simvastatin sodium salt
≥95% (HPLC), liquid, L-type calcium channel blocker, Calbiochem®
Synonym(s):
InSolution Simvastatin, Sodium Salt, L-Type Calcium Channel Blocker VI
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C25H39O6 · Na
Molecular Weight:
458.56
UNSPSC Code:
51111800
NACRES:
NA.77
Recommended Products
product name
Simvastatin, Sodium Salt, InSolution, ≥95%
Quality Level
assay
≥95% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
protect from light
shipped in
ambient
storage temp.
−70°C
General description
Carboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free assays. A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+-signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. The solid form of Simvastatin, Sodium Salt (Cat. No. 567021) is also available.
Carboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free assays. A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+-signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. The solid form of this compound (Cat. No. 567021) is also available.
Biochem/physiol Actions
Cell permeable: yes
Reversible: yes
Packaging
Packaged under inert gas
Warning
Toxicity: Irritant (B)
Physical form
A 10 mM (5 mg/1.09 ml) solution of Simvastatin, Sodium Salt (Cat. No. 567021) in H₂O.
Reconstitution
Following initial thaw, aliquot and freeze (-70°C).
Other Notes
Yada, T., et al. 1999. Br. J. Pharmacol.126, 1205.
Clutterbuck, R.D., et al. 1998. Br. J. Haematol.102, 522.
Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol.94, 87.
Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta1345, 259.
Vrtovsnik, F., et al. 1997. Kidney Int.52, 1016.
Keyomarsi, K., et al. 1991. Cancer Res.51, 3602.
Clutterbuck, R.D., et al. 1998. Br. J. Haematol.102, 522.
Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol.94, 87.
Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta1345, 259.
Vrtovsnik, F., et al. 1997. Kidney Int.52, 1016.
Keyomarsi, K., et al. 1991. Cancer Res.51, 3602.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
Sampath Katakam et al.
Life science alliance, 5(3) (2022-01-06)
Malignant tumors commonly display necrosis, which invariably triggers an inflammatory response that supports tumor growth. However, the effect on tumor cells of necrotic debris, or damage-associated molecular patterns (DAMPs) released by dying cells is unknown. Here, we addressed the effect
Luipa Khandker et al.
Cell reports, 38(9), 110423-110423 (2022-03-03)
Brain and spinal cord oligodendroglia have distinct functional characteristics, and cell-autonomous loss of individual genes can result in different regional phenotypes. However, a molecular basis for these distinctions is unknown. Using single-cell analysis of oligodendroglia during developmental myelination, we demonstrate
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service